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Effects of BCG vaccination on immunological characteristics of hematopoetic stem cells: an explorative study

To examine the effect of BCG vaccination on the composition and function of the bone marrow.

The added effect of oral ondansetron to care-as-usual on persisting
vomiting in children aged 6 months to 6 years, presenting at primary care
out of hours service with acute gastro-enteritis and concomitant vomiting

The primary objective is to determine the added effect of oral ondansetron to care-as-usual (including ORT) (CAU) on persisting vomiting within the first 4 hours after presentation at an out-of-hours primary care service (OHS) in children aged 6…

Effectiveness of a prenatally implemented parenting support intervention on preventing postpartum parental distress and enhancing infant well-being.

The primary objective is to assess the effect of the parenting support intervention on parental stress. Secondary objectives are the effect of theintervention on other parental outcomes (anxiety and depression, satisfaction with the parental role,…

A placebo-controlled, double-blind, randomized trial to compare the effect of treatment on plaque burden as determined by intravascular ultrasound and to evaluate the efficacy, pharmacokinetics, safety, and tolerability of MDCO-216 given as multiple weekly infusions in subjects with a recent acute coronary syndrome.

Primary ObjectivesTo evaluate the effect of MDCO-216 treatment on the change in PAV of a target coronary artery as measured by IVUS imaging following five weekly infusions of MDCO-216 (20 mg/kg) compared with placebo in subjects with a recent ACS.…

Role of different phosphate binders on absorption of vitamin K, metabolism of matrix *-carboxy-glutamaat (Gla) proteïne (MGP).

This research will have as aim to look at progression or decrease of vascular calcification in dialysis population with use of different phosphate binders. There is a possibility that differect phosphate binders bind vitamin K in a different way in…

Influence of early goal-directed therapy using arterial waveform cardiac output measurement in high-risk surgery

To determine whether early goal-directed therapy, aimed at optimizing cardiac output measured by arterial waveform analysis, improves outcome in high-risk, abdominal surgery.

*Multi-Site RCT of Group Schema Therapy for Borderline Personality Disorder*

Our long-range goal is to develop a comprehensive, clinically and cost effective treatment for BPD that produces both symptom remission and functional recovery. We aim to determine the role that group ST can have in the comprehensive treatment of…

The effect of concentrated beetroot juice with or without vitamin C on the levels of N-nitroso compounds in urine

The main aim of the study will be to compare the urinary N-nitroso compounds levels after intake of 70 ml of concentrated red beetroot juice containing 400 mg nitrate either with or without supplementation with 1 g vitamin C.

Volar Internal Plate Fixation versus Plaster in Extra-articular distal Radial fractures (VIPER)

To compare the functional outcome of ORIF with a volar locking plate to closed reduction and plaster immobilisation in patients with dislocated extra-articular distal radius fractures.

Dose response of DHA and vitamin supplements during pregnancy and lactation to increase the breast milk DHA content to 0.7-1.0 g%.

The primary aim of this study is to find the dose of DHA during pregnancy and lactation that leads to a mean breastmilk DHA of at least 0.7g%.

Feasibility study of a smart ankle foot orthosis in people with paretic ankle muscles

The objective of this feasibility study is compare the smart AFO + standardized shoes to subjects* own AFO + own shoes. Subjects* experiences with the orthotic devices will be evaluated and points for improvement will be asked. Subjects* performance…

A randomised, double-blind, parallel group PhIII study to assess the clinical efficacy and safety of 100 mg SC Mepolizumab as an add on to maintenance treatment in adults with severe bilateral nasal polyps (study 205687, SYNAPSE)

Primary:To evaluate the efficacy of 100mg mepolizumab compared to placebo.Secondary:The impact on actual nasal surgery. Further efficacy assessment. Quality of life.

The effect of individualized NUTritional counselling on muscle mass and treatment outcome in patients with metastatic COLOrectal cancer undergoing chemotherapy: the COLONUT study

To study the effect of individualized nutritional counselling compared to usual nutritional care on cross-sectional muscle area in patients with stage IV colorectal cancer during first-line chemotherapy. Secondary, effect on total lean body mass,…

*Long-term effects of arthroscopic meniscal allograft transplantation: clinical and subjective evaluation 5 years postoperative * a prospective cohort study*

To determine the long-term effects of meniscal allograft transplantation with regard to the radiological and patient related outcome (PRO), and the correlation between the two. The preoperative data of the MRI, Dual-energy X-ray Absorptiometry (DXA…

A randomised comparison of Eye Movement Desensitization and Reprocessing (EMDR), Narrative Exposure Therapy (KIDNET) and waiting list control in traumatized refugee children.

The study aims to answer the following research questions:1. How high/low are levels of symptomatology of depression and/or PTSD in traumatised refugee children in ASC?2. Do symptom levels decrease after a short-term trauma-focused intervention?3.…

Neo-adjuvant chemotherapy followed by surgery versus surgery alone in high-risk patients with resectable colorectal liver metastases ;The CHARISMA randomized multicenter clinical trial

The primary study objective is to compare the efficacy, as assessed by overall survival, of surgery and neo-adjuvant chemotherapy to surgery alone in patients with resectable liver metastases of colorectal cancer and a high clinical risk score.…

SUCCESS STUDY; Smoking reduction by a smoking cessation strategy in the national cervical cancer screening program

We hypothesize that a smoking cessation strategy for smoking cervical cancer screening participants will increase their motivation to quit and will lead to an increased proportion of smokers performing a serious quit attempt. Eventually this will…

Stimulation of the sphenopalatine ganglion with the ATI Neurostimulation system for cluster headache treatment

We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).

Movement in Trauma. An explorative study on the effects of a psychomotor intervention in the first phase of treatment for patients with complex trauma.

Aim of the study is to gain insight in the results of a new intervention and to compare these with the results of the treatment for complex PTSD as it is now offered . It is also our goal to gain information on how patient characteristics and…

Implicit and explicit home-based training programs for young children with cerebral palsy: process evaluation and effectiveness on bimanual performance and parental stress

To assess fidelity (quality), dose delivered (completeness), dose received (exposure and satisfaction), recruitment and context of two newly developed upper limb home-based training programs, i.e. one based on implicit strategies and one based on…