24 results
To determine whether early goal-directed therapy, aimed at optimizing cardiac output measured by arterial waveform analysis, improves outcome in high-risk, abdominal surgery.
The primary objective of the present study is to demonstrate that NT-proBNP guidance during in-hospital treatment for acutely decompensated heart failure (to strive for >30% reduction) reduces readmissions and mortality and increases the…
The objective of the study is to obtain information on the bioavailability and pharmacokinetics of the phenolics present in an olive leaf extract (Bonolive®, dose 250 mg), standardized on 40% oleuropein, and to identify the composition of the…
Determine the safety and efficacy of Tiscover compared to AS210 (acellular donor dermis, construct Tiscover is cultured on) for the treatment of chronic, therapy resistant (arterio-) veneus leg/foot ulcers in an out patient setting.
This study has two main objectives:1. To assess the efficacy of hypnotherapy on symptoms and quality of life in IBS patients;2. To compare the efficacy of individual hypnotherapy with a group application of hypnotherapy in IBS treatment.
Primary Study Objective:To assess the efficacy and safety of the co-administration of low-dose pegvisomant (40 mg, administered via subcutaneous injection given once a week) and long-acting somatostatin analogs (administered once monthly) on the…
This study is designed to investigate whether it is possible to achieve substantial improvement of HbA1c values in preconceptional suboptimal regulated type 1 diabetes mellitus (which is HbA1c 7.0-7.7%). Primary outcome- Absolute reduction in…
In this study the relation of OSAS with functional status and cognition, and the effect of treatment with CPAP on outcomes of rehabilitation in stroke patients will be investigated. The main research questions are: 1) Is there a relationship between…
Establishing the pharmacokinetics of intranasally and intramuscularly administered cobalamin in elderly.
The primary objective of this trial is to determine the clinical and cost effectiveness of computerized cognitive behavioural therapy with therapist support, compared to face-to face therapy based on cognitive-behavioural techniques for mild to…
To study the effect of alleviation of obstructive cholestasis by biliary drainage with or without rifampicin on serum bilirubin levels, quality of life, itch intensity, and serum and/or biliary bile salt, ATX, LPA, FGF-19 and biliary HCO3- levels in…
Primary objective: To assess the efficacy of reducing the sleep time in supine posture with positional therapy using the position training device compared to the sleep position band in patients with mild and moderate positional OSAS.Secondary…
The primary objective of this study is to investigate if monitoring weight by tele-monitoring and its procedure in oncology and COPD patients results in less weight loss (or in weight gain), compared to the control group.The secondary objective of…
To gain insight in the humoral and cellular immune response of people with risk factors for chronic Q-fever after vaccination against Q-fever and of people who have had a natural infection or have a chronic infection.
To study the impact of laser photocoagulation on the parafoveal visual field in a previously untreated population of patients with DME.
The main objectives of this study are to evaluate the effects of HIT in CHF patients on cardiac output at rest assessed with cardiac magnetic resonance imaging(cMRI), and to investigate the relation between changes in resting cardiac output and…
In this study two treatment groups will be compared: ACP injection in combination with exercise therapy and placebo injection in combination with exercise therapy.
The purpose of this study is to investigate the clinical effectiveness of a self management group intervention for stroke patients with social reintegration problems and their partners compared to a control group education intervention. The main…
The objective of this study is to determine the application of the prosthesis simulators and the bimanual transfer effects in the existing rehabilitation programs for patients who will obtain an upper limb prosthesis.At first it needs to be revealed…
To detemine the optimal imaging modality and moment in time to delineate RT target volumes in breast-conserving therapy.