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A placebo-controlled, double-blind, randomized trial to compare the effect of treatment on plaque burden as determined by intravascular ultrasound and to evaluate the efficacy, pharmacokinetics, safety, and tolerability of MDCO-216 given as multiple weekly infusions in subjects with a recent acute coronary syndrome.

Primary ObjectivesTo evaluate the effect of MDCO-216 treatment on the change in PAV of a target coronary artery as measured by IVUS imaging following five weekly infusions of MDCO-216 (20 mg/kg) compared with placebo in subjects with a recent ACS.…

Feasibility study of a smart ankle foot orthosis in people with paretic ankle muscles

The objective of this feasibility study is compare the smart AFO + standardized shoes to subjects* own AFO + own shoes. Subjects* experiences with the orthotic devices will be evaluated and points for improvement will be asked. Subjects* performance…

*Long-term effects of arthroscopic meniscal allograft transplantation: clinical and subjective evaluation 5 years postoperative * a prospective cohort study*

To determine the long-term effects of meniscal allograft transplantation with regard to the radiological and patient related outcome (PRO), and the correlation between the two. The preoperative data of the MRI, Dual-energy X-ray Absorptiometry (DXA…

Stimulation of the sphenopalatine ganglion with the ATI Neurostimulation system for cluster headache treatment

We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).

Movement in Trauma. An explorative study on the effects of a psychomotor intervention in the first phase of treatment for patients with complex trauma.

Aim of the study is to gain insight in the results of a new intervention and to compare these with the results of the treatment for complex PTSD as it is now offered . It is also our goal to gain information on how patient characteristics and…

Off-label use of Risperidone in Children and Adolescents (ORCA): a double-blind placebo-controlled discontinuation trial

Primary Objective: To investigate the behavioral effects of controlled discontinuation as well as the feasibility of discontinuing currently ongoing treatment with risperidone in children and adolescents with behavioral problems who have used…

Node study: 'Esophageal resection for patients with esophageal cancer and cervical lymph node metastases'

To assess the safety and feasibility of curative esophagectomy combined with three field lymphadenectomy after chemo-radiation in Western patients with resectable thoracic esophageal carcinoma and cervical lymph node metastases in level III and/ or…

a phase III randomised trial of intravesical chemotherapy vs thermo-chemotherapy in intermediate risk non-muscle invasive bladder cancer

To compare standard treatment with intravesical chemotherapy with loco-regional thermo-chemotherapy in patients with an intermediate risk non-muscle invasive urothelial carcinoma of the bladder after complete transurethral resection of the tumour(s…

Feasibility of standard therapy with temozolomide and radiotherapy combined with ketogenic diet in patients with glioblastoma multiforme

Primary objective:To assess the feasibility of KD in patients with glioblastoma multiforme during standard treatment.Secundary objectives:- To determine number of patients not being able to start protocol treatment (i.e. not able to reach ketosis,…

The effect of arabinose on sucrose hydrolysis by sucrase and glucose absorption and glycaemic response

The primary objective is to quantify and compare the effect of added arabinose to sucrose containing liquid and solid food products on glycaemic response and sucrose hydrolysis by sucrase and glucose absorption in healthy humans.The secundary…

Comparison of femoral nerve block with posterior capsule infiltration versus anterior and posterior capsule infiltration after total knee replacement.

This prospective randomized controlled trial designed to compare the quality of analgesia offered by SFNB and LIA and their effects on morphine consumption, mobilization and pain control postoperatively. Our first hypothesis concerning opioid use is…

The use of a patellar strap in athletes with a jumper*s knee: A pilot study on the effect on proprioception, tendon structure and symptoms

Primary Objective: Getting insight in the effect of the use of the Genupoint patellar strap on knee joint proprioception in subjects with patellar tendinopathy.Secondary Objective(s): Getting insight in the effect of the use of the Genupoint…

A pilot study concerning the effectiveness and practice of well-being therapy in the treatment of outpatients with a mild anxiety disorder or a mild depression.

Firstly this study tries to answer the question whether applying well-being therapy to outpatients with a mild affective disorder in Dutch mental health care, reveals a trend in which well-being is increased and psychiatric complaints are reduced.…

Epifysiodesis for adolescents; What is the most effective postoperative pain treatment? An RCT

What is the effectiveness of an epidural painmanagement compared with a PCA method as postoperative treatment after an epiphysiodesis for adolescents during the first 5 days after the procedure?

A randomized waiting-list controlled study on the efficacy and cost effectiveness of blended treatment to reduce anxiety in children with Anxiety disorders and possible comorbid ADHD, ASD or mental disability.

The main objective of the study is to evaluate the efficacy of the *Blended Coping Cat* program in reducing anxiety levels in children diagnosed with anxiety disorders and possible ADHD, ASD, mild intellectual disability or borderline intellectual…

The effect of oral ondansetron on referral rate in children aged 6 months to 6 years attending in primary care out of hours service with acute gastro-enteritis and vomiting.

The primary objective is to study the effect of oral Ondansetron and oral rehydration therapy on the number of referrals to a pediatric emergency department in children aged 6 months to 6 years attending an out-of-hours primary care service (OHS)…

Inhaler instruction in patients with asthma or COPD: can it be improved?

to investigate the additional value of the use of inhaler specific instruction cards in inhaler education in patients with asthma or COPD.

The use of a patellar strap in children with Osgood-Schlatter disease: a pilot study of the short term effect on symptoms and sports participation.

Primary objective:The purpose of this study is to evaluate the short term effect of a patellar strap on symptoms and sports participation in children with Osgood-Schlatter disease.Secondary objective: The second objective of this study is to…

Discontinuation versus continuation of antiarrhythmic drugs prior to pulmonary vein isolation for atrial fibrillation and influence on dormant conduction with adenosine; a randomised controlled trial.

Comparing incidence of dormant conduction after adenosine challenge and initial succesfull PVI in a strategy of cessation of antiarrhythmic drugs compared with continuation prior to PVI.

A clinical prospective feasibility study to address the effectiveness and safety of calciumphosphate/poly(lactic-co-glycolic-acid) for bone augmentation in maxillary sinus floor elevation surgery.

The primary objective is to determine the feasibility of applying CPC-PLGA in sinus floor elevation surgery in terms of bone formation and implant survival. The secondary objective is to investigate pain, health-related quality of life and the…