Search for a trial

A randomised, double-blind, parallel group PhIII study to assess the clinical efficacy and safety of 100 mg SC Mepolizumab as an add on to maintenance treatment in adults with severe bilateral nasal polyps (study 205687, SYNAPSE)

Primary:To evaluate the efficacy of 100mg mepolizumab compared to placebo.Secondary:The impact on actual nasal surgery. Further efficacy assessment. Quality of life.

SUCCESS STUDY; Smoking reduction by a smoking cessation strategy in the national cervical cancer screening program

We hypothesize that a smoking cessation strategy for smoking cervical cancer screening participants will increase their motivation to quit and will lead to an increased proportion of smokers performing a serious quit attempt. Eventually this will…

Beginning to unravel the cause of familial hypercholesterolemia of unknown origin (FH4)

To unravel the cause(s) of the FH phenotype in patients with no mutations in well-established lipid genes (LDLR, APOB, PCSK9).

A Randomized, Placebo-controlled, Double-blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Oral Doses of LTI-291 in Healthy Middle-Aged to Elderly Subjects

- To evaluate the safety and tolerability of four oral dose levels of LTI-291 following multiple administrations in healthy middle-aged to elderly subjects. - To characterize the plasma and cerebrospinal fluid (CSF) pharmacokinetics (PK) of LTI-291…

Randomized, double-blind, double-dummy, placebo-controlled, four-way crossover single dose
study to determine the test-retest reliability of, and the effect of oral valproic acid, levetiracetam and
lorazepam on, cortical excitability measurements in healthy volunteers as measured by TMS-EEG and TMS-EMG.

Primary Objective- To investigate the ability of TMS-EEG measures to detect effects on cortical excitability of valproic acid, levetiracetam and lorazepam in healthy subjects- To investigate the ability of TMS-EMG measures to detect effects on…

Burden of burn injuries: quantifying the societal impact of burns with a state-of-art burden of disease methodology

To obtain a comprehensive overview of long-term (*5 years after burn injury) consequences after burn injuries, both in all patients admitted to burn centre admissions and in a subgroup of patients who suffered from more extensive burns.

Stimulating physical activity in children with asthma

The SIMBA project is a research collaboration in which children with asthma, their parents and healthcare professionals play an important role. The SIMBA study is a two year program that aims to develop and finally (pilot) test an exercise game that…

Which treatment works for whom? A comparison of sound-exposure therapies

Primary research questions:1. Does tinnitusspecific- behavioural exposure-treatment (T-BET) decrease tinnitus-related fear, tinnitus-severity and enhance recovery, when compared to a masking-therapy with use of personalised on-ear masking-devices,…

Open label, randomized, cross-over study to explore the pharmacokinetics of BAY 1834845 after oral and intravenous dosing, including food effect and absolute bioavailability (Part A), and to investigate the effect of BAY 1834845 on the pharmacokinetics of orally administered methotrexate (Part B) in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent BAY 1834845 is absorbed and eliminated from the body (this is called pharmacokinetics). In both study parts it will also be investigated to what extent BAY 1834845 is…

Oro-sensory exposure, eating rate and satiation

The primary objective of this study is to determine the independent and additive effects of oro-sensory exposure (mastication effort) and ingestion rate (bite interval) on satiation in relation to the cephalic endocrine and metabolic hormonal…

Lexical Production and Cognitive Control in Bilinguals

Thus far, what previous literature has dealt with, addresses the neural mechanisms involved in L1 and L2 lexical production separately (e.g. Hernandez & Meschyan, 2006; Liua et al., 2010; Reverberi et al., 2015), irrespective of any…

A prospective trial on the clinical efficacy of the Ankle Spacer for the surgical treatment of large, multiple, cystic and secondary or tertiary osteochondral defects of the talus.

* Primary Objective: determine the functional outcome and clinical efficacy after open surgical implantation of the Ankle Spacer for patients with large, cystic, previously surgically failed and/or multiple OCDs of the talus by means of functional…

An exploratory, multicenter, placebo-controlled, randomized, double-blind study to investigate the antidepressant mechanism-of-action of JNJ-42847922 in subjects with major depressive disorder.

To investigate the effect of JNJ-42847922 given as monotherapy as compared to placebo on symptoms of depression in male and female MDD patients

A First-in-Human Randomized, Placebo-controlled, Double-blind, Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Oral Doses of LTI-291 in Healthy Subjects

- To evaluate the safety and tolerability of four different single oral doses of LTI-291 in healthy subjects.- To characterize the plasma pharmacokinetics (PK) of LTI-291 following single oral dosing in healthy subjects.- To evaluate the…

rational rehabilitation in therapy resistant PTSS

to reduce ptsd symptoms and psychological suffering in general, and to improve quality of life

Cognitive behavioral therapy for Misophonia, RCT

To evaluate the effect of the CBT groep treatment for misophonia.

Understanding gut feelings: Probiotics and cognition

Translating these animal findings to humans is one of the aims of the current study. The proposed project aims to replicate the aforementioned preliminary findings (Evrensel & Ceylan, 2015; Steenbergen et al., 2015; de Noos et al., 2015;…

A 2-Part, Randomized, Placebo-controlled, Double-blind, Single Ascending Dose Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-55375515 in Healthy Male Subjects

The purpose of this study is to investigate how safe the new compound JNJ55375515 is when it is administered to healthy subjects. JNJ-55375515 has been administered to humans before and will be investigated at various dose levels.It will also be…

Does virtual reality gait training improve participation after a stroke?

The objective of this study is to investigate the effect of virtual reality training, given between 2 weeks and 6 months after stroke, on participation and subjective physical functioning in independently living patients .Primary research question:…

Perception of Indexical Cues in Kids and Adults

The main objective of this study is to investigate the developmental trajectory of the perception of voice characteristics in children and how it relates to the recognition of gender, emotions, and linguistic processing in CI children, in comparison…