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rational rehabilitation in therapy resistant PTSS

to reduce ptsd symptoms and psychological suffering in general, and to improve quality of life

How effective is local treatment of Molluscum Contagiosum compared to whatchful waiting?

The aim of this study is to compare the effect of early treatment on healing and quality of life with the usual expectant policy in children with mollusca contagiosa.

OptIcal MetAstatic Guidance in mInimally iNvasive Esophagectomy: a multicentre phase I/II diagnostic study

The aim of this present feasibility study is to determine the safety and preliminary accuracy by which we can intra-operatively detect residual disease in esophageal tumor and lymph nodes. This study is set up as a prospective multi-centre dose…

Nervus X- Atrial Fibrillation trial (NX-AF)

The primary objective is to examine the impact of t-LLVS on electrophysiological properties of the atria and ventricles. Secondary objectives are:- to elucidate the correlation between proteostasis marker levels in serum and atrial tissue, and the…

Intensive Care Unit specific Virtual Reality for family members (ICU-VR-F) of patients in the ICU.

Our primary objective is to determine the effect of ICU-VR-F on symptoms of depression, anxiety and PTSD, and the health-related quality of life (HRQoL) in family members of ICU patients. The secondary objective is to determine the effect of ICU-VR-…

A Single-Dose, Open-Label, Randomized, Replicate Crossover Pivotal Bioequivalence Study in Healthy Subjects to Assess the Bioequivalence of Darunavir 675 mg, Emtricitabine 200 mg, and Tenofovir Alafenamide 10 mg in the Presence of Cobicistat 150 mg when Administered as a Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared to the Coadministration of the Separate Agents (Darunavir, Cobicistat, and Emtricitabine/Tenofovir Alafenamide), Under Fed Conditions

- To evaluate the single-dose PK and pivotal bioequivalence of 3 compounds darunavir (DRV) 675 mg, FTC 200 mg, and tenofovir alafenamide (TAF) 10 mg in the presence of cobicistat (COBI)150 mg when administered as an fixed-dose combination (FDC) (D/C…

The enrichment of the fat graft in facial fat grafting for increased volume retention

The comparison of standard fat grafting with enriched fat grafting.

Complement Inhibition: Attacking the Overshooting Inflammation @fter Traumatic Brain Injury ( A phase II trial on the safety and efficacy of C1 esterase inhibitor Cinryze for the acute management of severe traumatic brain injury)

This study has been transitioned to CTIS with ID 2024-514488-24-01 check the CTIS register for the current data. Primary Objective: To determine the safety and efficacy of 6000 IU Cinryze in patients with moderate and severe TBI (GCS <13 with…

Revised Evaluation of Surgery in Elderly with Traumatic Acute SubDural Hematoma (RESET-ASDH study)
Survival and quality of life after early surgical intervention versus wait-and-see in elderly patients with a traumatic acute subdural hematoma (ASDH): an international multicenter prospective cohort study

To compare the (cost-)effectiveness of early surgical hematoma evacuation versus a conservative treatment in elderly patients with a traumatic ASDH.

Study on the potential pharmacokinetic interaction between cannabidiol (CBD) and tamoxifen in patients with primary breast cancer

To determine the potential pharmacokinetic interaction between CBD and endoxifen.Secondary objective: To investigate side effects of CBD and to determine the pharmacokinetic profile of CBD

Precision Medicine for more Oxygen - COVID-19 extension

Therefore, the Precision Medicine for more Oxygen (P4O2) program aims to identify treatable traits and innovative personalized therapeutic strategies to both prevent progression of early stage lung damage and to reverse established lung damage by…

A Phase III, Randomized, Multicenter, Double-blind, Placebo-controlled
Study of Durvalumab for the Treatment of Stage II-III NSCLC Patients
with Minimal Residual Disease Following Surgery and Curative Intent
Therapy (MERMAID-2)

This study is being conducted to evaluate the efficacy and safety of durvalumab adjuvant therapy compared to placebo in patients with completely resected stage II-III NSCLC who have undergone curative intent therapy (complete resection ± neoadjuvant…

Optimal postoperative Pain management After Lung surgery (OPtriAL): multi-centre randomised trial

The main objective is to compare regional continuous paravertebral block (PVB), single shot multi-level intercostal nerve block (ICNB) and thoracic epidural analgesia (TEA) as pain relief techniques in order to provide safe, effective and efficient…

A Prospective, Multicenter, Single-Arm, Open-Label, Phase 4 Study of the Effects of Selexipag on Right Ventricular Remodeling in Pulmonary Arterial Hypertension Assessed by Cardiac Magnetic Resonance Imaging. (RESTORE)

Main objective:To assess the effects of selexipag on right ventricular (RV) function in participants with PAH.Secondary objectives:- To further assess the effects of selexipag on RV function using MRI.- To assess the effects of selexipag on disease…

Feasibility study: The effect of the low FODMAP diet on women suffering from endometriosis

This study aims to create an indication of the effect size during and after adherence to the low FODMAP diet to calculate a sample size for a future RCT on this subject.

A Non-Randomized, Open Label, Adaptive, Single Center, Positron Emission Tomography (PET) Study to Assess Distribution of RO7248824 in the Central Nervous System Following Single Intrathecal Doses of [89Zr]-Labeled RO7248824 in Healthy Male Participants

The new compound RO7248824 is being developed for the treatment of Angelman syndrome (AS). The purpose of this study is to find out how RO7248824 spreads in the brain and spine after injection into the spinal canal (intrathecal administration). This…

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Nemolizumab (CD14152) in Subjects with Moderate-to-Severe Atopic Dermatitis

Primary objective: The primary objective is to assess the efficacy and safety of nemolizumab (CD14152) after a 16-week treatment period in adult and adolescent subjects with moderate-to-severe atopic dermatitis (AD) not adequately controlled with…

Comparison of non-invasive bedside methods to estimate central venous pressure

To compare the accuracy of the above-mentioned methods in patients admitted to the ward or intensive care unit in estimating CVP and to investigate the correlation between the different methods.

Early detection of Barrett's esophagus and esophageal cancer: accuracy and acceptability of a novel screening strategy in primary care.

To determine the accuracy and acceptability of a minimal-invasive screening strategy (breath testing (eNose) followed by unsedated transnasal endoscopy (uTNE)) for Barrett*s esophagus (BE) and esophageal adenocarcinoma (EAC).

Extension of the randomized, double-blind, placebo-controlled single ascending dose study to assess the safety and tolerability of AP30663 in healthy subjects.

Primary ObjectivesTo evaluate the safety and tolerability of AP30663 in healthy males at doses up to 12mg/kgExploratory ObjectiveTo evaluate the effect of AP30663 on electrocardiographical parameters.