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A randomised, double-blind, parallel group PhIII study to assess the clinical efficacy and safety of 100 mg SC Mepolizumab as an add on to maintenance treatment in adults with severe bilateral nasal polyps (study 205687, SYNAPSE)

Primary:To evaluate the efficacy of 100mg mepolizumab compared to placebo.Secondary:The impact on actual nasal surgery. Further efficacy assessment. Quality of life.

SUCCESS STUDY; Smoking reduction by a smoking cessation strategy in the national cervical cancer screening program

We hypothesize that a smoking cessation strategy for smoking cervical cancer screening participants will increase their motivation to quit and will lead to an increased proportion of smokers performing a serious quit attempt. Eventually this will…

Beginning to unravel the cause of familial hypercholesterolemia of unknown origin (FH4)

To unravel the cause(s) of the FH phenotype in patients with no mutations in well-established lipid genes (LDLR, APOB, PCSK9).

A Randomized, Placebo-controlled, Double-blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Oral Doses of LTI-291 in Healthy Middle-Aged to Elderly Subjects

- To evaluate the safety and tolerability of four oral dose levels of LTI-291 following multiple administrations in healthy middle-aged to elderly subjects. - To characterize the plasma and cerebrospinal fluid (CSF) pharmacokinetics (PK) of LTI-291…

Randomized, double-blind, double-dummy, placebo-controlled, four-way crossover single dose
study to determine the test-retest reliability of, and the effect of oral valproic acid, levetiracetam and
lorazepam on, cortical excitability measurements in healthy volunteers as measured by TMS-EEG and TMS-EMG.

Primary Objective- To investigate the ability of TMS-EEG measures to detect effects on cortical excitability of valproic acid, levetiracetam and lorazepam in healthy subjects- To investigate the ability of TMS-EMG measures to detect effects on…

Burden of burn injuries: quantifying the societal impact of burns with a state-of-art burden of disease methodology

To obtain a comprehensive overview of long-term (*5 years after burn injury) consequences after burn injuries, both in all patients admitted to burn centre admissions and in a subgroup of patients who suffered from more extensive burns.

Stimulating physical activity in children with asthma

The SIMBA project is a research collaboration in which children with asthma, their parents and healthcare professionals play an important role. The SIMBA study is a two year program that aims to develop and finally (pilot) test an exercise game that…

Which treatment works for whom? A comparison of sound-exposure therapies

Primary research questions:1. Does tinnitusspecific- behavioural exposure-treatment (T-BET) decrease tinnitus-related fear, tinnitus-severity and enhance recovery, when compared to a masking-therapy with use of personalised on-ear masking-devices,…

Open label, randomized, cross-over study to explore the pharmacokinetics of BAY 1834845 after oral and intravenous dosing, including food effect and absolute bioavailability (Part A), and to investigate the effect of BAY 1834845 on the pharmacokinetics of orally administered methotrexate (Part B) in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent BAY 1834845 is absorbed and eliminated from the body (this is called pharmacokinetics). In both study parts it will also be investigated to what extent BAY 1834845 is…

Oro-sensory exposure, eating rate and satiation

The primary objective of this study is to determine the independent and additive effects of oro-sensory exposure (mastication effort) and ingestion rate (bite interval) on satiation in relation to the cephalic endocrine and metabolic hormonal…

Lexical Production and Cognitive Control in Bilinguals

Thus far, what previous literature has dealt with, addresses the neural mechanisms involved in L1 and L2 lexical production separately (e.g. Hernandez & Meschyan, 2006; Liua et al., 2010; Reverberi et al., 2015), irrespective of any…

A prospective trial on the clinical efficacy of the Ankle Spacer for the surgical treatment of large, multiple, cystic and secondary or tertiary osteochondral defects of the talus.

* Primary Objective: determine the functional outcome and clinical efficacy after open surgical implantation of the Ankle Spacer for patients with large, cystic, previously surgically failed and/or multiple OCDs of the talus by means of functional…

An exploratory, multicenter, placebo-controlled, randomized, double-blind study to investigate the antidepressant mechanism-of-action of JNJ-42847922 in subjects with major depressive disorder.

To investigate the effect of JNJ-42847922 given as monotherapy as compared to placebo on symptoms of depression in male and female MDD patients

A First-in-Human Randomized, Placebo-controlled, Double-blind, Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Oral Doses of LTI-291 in Healthy Subjects

- To evaluate the safety and tolerability of four different single oral doses of LTI-291 in healthy subjects.- To characterize the plasma pharmacokinetics (PK) of LTI-291 following single oral dosing in healthy subjects.- To evaluate the…

Impulsivity, a risk factor in relapse to substance use disorder: investigating neural substrates before and after pharmacological challenges.

The goals of the proposed study are: (1) to further elucidate the relations between impulse control, motivational strength of drug cues, and brain activation patterns (using fMRI); (2) to examine the relative strength by which these processes are…

The (cost)effectiveness of paricalcitol in the treatment of secondary hyperparathyroidism in hemodialysis patients.

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PREdictive value of the Self-triagecard and Chlamydia trachomatis positivity rate in vocational School students (PRESS-study)

This study assesses the prevalence of CT and GC in vocational school students and assesses the validity and feasibility of the self-triagecard as a method to efficiently identify and treat CT positive youth and limit the spread of CT.

Organ protection by noble gases - helium therapy in acute ischemic stroke

The primary objective is to investigate the feasibility and the safety of heliox administration, a gaseous mixture of 79% helium en 21% oxygen, for 8 hours in acute ischemic stroke.

Diagnostic Imaging of Affective Disorders using Emotion-processing (DIADE) A neuroimaging study to determine biomarkers to discriminate unipolar and bipolar depression

We aim to (1) improve differential diagnosis of recurrent MDD and BD by investigating biomarkers at a neuropsychological and neurobiological level; (2) investigate whether affective neuropsychological testing can be used as a diagnostic tool for MDD…

Effects of social exclusion on dopamine function in the human brain. An [123I]Iodobenzamide SPECT study in young adults with serious hearing impairment.

To test the following hypotheses:1. The baseline [123I]IBZM binding potential ([123I]IBZM-BP) in the ventral striatum is smaller in patients with SAHI than in healthy subjects, due to increased baseline activity of the mesolimbic dopamine system. 2…