99 results
To determine whether early goal-directed therapy, aimed at optimizing cardiac output measured by arterial waveform analysis, improves outcome in high-risk, abdominal surgery.
Our long-range goal is to develop a comprehensive, clinically and cost effective treatment for BPD that produces both symptom remission and functional recovery. We aim to determine the role that group ST can have in the comprehensive treatment of…
The primary objective of the present study is to demonstrate that NT-proBNP guidance during in-hospital treatment for acutely decompensated heart failure (to strive for >30% reduction) reduces readmissions and mortality and increases the…
The objective of the study is to obtain information on the bioavailability and pharmacokinetics of the phenolics present in an olive leaf extract (Bonolive®, dose 250 mg), standardized on 40% oleuropein, and to identify the composition of the…
To optimize the management of non-chronic shoulder pain in primary care by the introduction of ultrasound as a diagnostic triage tool. The following research questions will be addressed:1. What are the effects of diagnostic ultrasound and its…
The primary aim of our study is to evaluate safety and toxicity of ex vivo-expanded NK cell infusions following a non-myeloablative conditioning regimen in elderly AML patients who are no candidates for allogeneic SCT. Moreover there is also a…
To assess the effects of a 4-week high protein diet on body composition in obese children. Secondary outcomes are whole-body protein turnover, gluconeogenesis, energy expenditure, markers of the metabolic syndrome, appetite sensations,…
The objective of our study is to to assess the diagnostic performance of 7T CE breast MRI in comparison to the current clinical standard of 3T MRI and histopathology on a intra-individual basis.
Determine the safety and efficacy of Tiscover compared to AS210 (acellular donor dermis, construct Tiscover is cultured on) for the treatment of chronic, therapy resistant (arterio-) veneus leg/foot ulcers in an out patient setting.
This study has two main objectives:1. To assess the efficacy of hypnotherapy on symptoms and quality of life in IBS patients;2. To compare the efficacy of individual hypnotherapy with a group application of hypnotherapy in IBS treatment.
To determine if adjusting endotracheal tube cuff pressure after placement of a retractor during anterior cervical spine surgery prevents postoperative dysphagia. Furthermore laryngo-tracheal complaints (hoarseness and sore throat) will be scored.
To compare the effectiveness of PVI and VATS-PVI. Secondary objectives are to compare the duration of hospitalisation, quality of Life, cost and to compare the satisfaction of the patients.
Primary Study Objective:To assess the efficacy and safety of the co-administration of low-dose pegvisomant (40 mg, administered via subcutaneous injection given once a week) and long-acting somatostatin analogs (administered once monthly) on the…
The primary objective of the REBEL study is to collect data needed to design control policies to diminish the spread of ESBL-producing Gram negative bacteria in the Dutch population.
This study is designed to investigate whether it is possible to achieve substantial improvement of HbA1c values in preconceptional suboptimal regulated type 1 diabetes mellitus (which is HbA1c 7.0-7.7%). Primary outcome- Absolute reduction in…
In this study the relation of OSAS with functional status and cognition, and the effect of treatment with CPAP on outcomes of rehabilitation in stroke patients will be investigated. The main research questions are: 1) Is there a relationship between…
Primary Objective: Primary endpoints will be renal (ERPF, GFR and FF) response to angiotensin II after low and high sodium diet in formerly preeclamptic patients compared to healthy controls. Secondary Objectives: Secondary endpoint will be systemic…
The objective is to investigate the effects of a combined strength and aerobic exercise program on cognition, physical functioning, social functioning and ADL.
The present study aims at comparing the post-operative lung injury of a lung*protective mechanical ventilation strategy (with the use of higher levels of PEEP and intra*operative recruitment maneuvers) with conventional mechanical ventilation (lower…
To understand more of the learning principles of vegetable consumption in young children (2-4 years). The aim of this study is to investigate the effect of flavour nutrient learning on vegetable preference and intake. Primary Objective: To…