89 results
To determine the contrast sensitivity, visual field and adaptation time at high light conditions.
We aim to develop a proxy-model of baseline dopamine based on machine learning methods which would provide us with behavioural predictors of the effects of dopaminergic drugs on brain and cognition that maximally generalize to new participants.
The main objective of this study is to assess whether multisensory stimulation (i.e., visuo-tactile cues), enhances the ability of hemispatial neglect patients to detect sensory stimuli presented on the neglected hemispace.
To evaluate the safety and efficacy of ReActiv8 for the treatment of adults with Chronic Low Back Pain and no prior spine surgery when used in conjunction with medical management.
Evaluation of a novel alternative protein source to stimulate post-exercise muscle protein synthesis
From p11 of C1 protocol document:1) To define the characteristics of mealworm protein ingestion on protein/digestion absorption kinetics and both whole-body and myofibrillar muscle protein synthesis after a single bout of resistance exercise in…
Primary Objective: To determine the prevalence of A1AT-pathology by genotype analysis of patients with DD and comparing this to a population without DD.Secondary Objective:To determine whether the population with A1AT pathology develops more often…
Primary: Feasibility of an in-house developed electromagnetic navigation system during real-time tumour tracking in rectal surgery.Secondary: Evaluation of the accuracy of the system. * Determine the accuracy of the navigation system relative to…
Primary objective:Assess the safety and efficacy of adalimumab prior to surgery in subjects with moderate to severe HS who are surgical candidates.Secondary objectives:Assess the impact of adalimumab on the planned HS surgical site before surgery,…
To evaluate the safety and efficacy of multiple doses of ABT-494 (Upadacitinib) monotherapy versus placebo in the treatment of adults with moderate to severe atopic dermatitis.
To determine the local and systemic immune profile, with emphasis on T lymphocytes, in pancreatic cancer patients; and monitor how these immune profiles are affected by treatment for individual patients.
Primary objective: To study whether we can replace ICA with noninvasive imaging (ultra low-dose CTA and MR-perfusion) to determine obstructing CAD, in patients scheduled for ICA. Secondary objectives:To establish a CTA and MR perfusion dataset to…
Overall ObjectiveThe objective of this RCT is to evaluate whether the Systematic Tool to Reduce Inappropriate Prescribing (STRIP) including STRIP assistant (STRIPA) implemented by an appropriately qualified team will lead to an improvement in…
Primary objective: To investigate the feasibility of PAM 2 in breast cancer imaging, characterizing the photoacoustic appearances of different types of malignant (stage 1A) and benign (stage 1B) lesions.Secondary objectives:- To test the measurement…
The objective is:(1) To test the efficacy of VRE versus CAU in 200 children undergoing surgery on the anxiety level of the child during induction of anesthesia (primary outcome), pre- and postoperative child anxiety, pre- and postoperative parental…
Can administration of scopolaminebutyl from the start of the dying phase prevent death rattle during the dying phase?
The purpose of the present study is to determine superiority in efficacy of a phase-based treatment (i.e., EMDR therapy preceded by Skills Training in Affective and Interpersonal Regulation, STAIR) versus trauma-focused treatment alone (i.e., EMDR…
To assess the difference in efficacy between two ultra-low doses (1 x 500 mg and 1 x 200 mg) and standard low dose (1 x 1000 mg) of RTX retreatment on the change in DAS28-CRP, compared to a pre-specified non-inferiority margin of 0.6, at 3 and 6…
Our primary objectives are 1) to discover and validate a treatment selection fMRI biomarker for allocating OCD patients to CBT or SSRIs, and 2) to determine the divergent longitudinal effects of SSRIs and CBT on functional and structural brain…
The aim of this study is to determine the separate and combined effects of expectancy manipulation and empathy manipulation during pre- and post-operative tonsillectomy analgesia care on clinical adult patients* outcomes (main outcome measures is…
Primary objectiveTo compare the effect on pulmonary vascular resistance (PVR) of an initial triple oral regimen (macitentan, tadalafil, selexipag) versus an initial dual oral regimen (macitentan, tadalafil, placebo) in newly diagnosed, treatment-…