32 results
The main objective of this study is to observe current AE treatment strategies and the treatment response of these strategies after 2 weeks in several hospitals. Secondary objectives are (1) to measure effect treatment on FeNO, eosinophils and…
To investigate the effect of nutritional prehabilitation on adverse events in patients with locoregionally advanced head and neck cancer, with low to medium risk of malnutrition and with radiological sarcopenia. To evaluate its effect on patient-…
The purpose of the VISABL-AFL study is to demonstrate safety and efficacy of RF ablation of type I atrial flutter (AFL) with the Vision-MR Ablation Catheter 2.0 in conjunction with the Osypka HAT 500 RF generator and irrigation pump. Data collected…
Primary ObjectiveTo assess the safety, feasibility and frequency of relapsing P. vivax PvW1 infection after experimental sporozoite-administered Controlled Human Malaria Infection (CHMI)Secondary ObjectivesTo assess the immune response to primary…
The aim of this study is to characterize the internal 1 µm polystyrene microplastic (PS-MP) exposure in various human tissues in healthy volunteers. For this, the uptake and excretion of a single microdose of 1 µm [14C]-labelled PS-MP is…
The main (primary) objective is to study the influence of sex on the pharmacokinetics (PK) of metoprolol in patients after CABG with heart valve surgery and patients with a STEMI/NSTEMI who are prescribed a standard dosage of metoprolol as part of…
To compare L-MILP with R-MILP for benign and pre-malignant lesions of the pancreas in high-volume centers, regarding:1. Peri- and postoperative outcomes in terms of COMPOS-panc left score, for non-inferiority2. Total hospital-related costs, for…
Why wait? (Cost)effectiveness of an online transdiagnostic therapy for patients and their loved ones
In the current study, we will analyze the (cost)effectiveness of an online, transdiagnostic positive psychology eHealth intervention for patients waiting for psychological out-patient treatment and their relatives. We expect that this intervention…
This study aims to evaluate and compare the long-term outcomes of tissue-level and bone-level single implants in the posterior region of the mandible or maxilla in patients with adequate bone for implant placement, with or without prior bone…
To elucidate whether reducing glycemic variability with hybrid closed-loop therapy inhibits the inflammatory response (e.g. leukocyte phenotype, cytokine production, inflammatory proteins) in people with T1DM. Our secondary objectives are to…
The main objective is to investigate if splintless approach improve the surgical accuracy of MMA for OSA. The secondary objectives are to assess the effect of splintless MMA on duration of surgery, blood loss, adverse events, respiration function,…
Post Market Clinical Follow-up Study on the Refobacin Revision-3 Bone Cement and its instrumentation
The objectives of this study are to confirm safety, performance and clinical benefits of the Refobacin Revision-3 Bone Cement and its instrumentation, when used in hip or knee revision surgeries, by analysis of standard scoring systems, radiographs…
Main objectives:a) examine and assess the (cost-)effectiveness of WHO*s Doing What Matters in Times of Stress (DWM) in reducing psychological distress, improving mental health, and enhancing work-related well-being and productivity compared to care-…
This study aims to assess the long-term impact of the POSE-2 procedure on weight loss, specifically focusing on the percentage of total weight loss (%TWL) over a 5-year follow-up period. Additionally, the durability and safety of the procedure will…
In this single-blinded randomized controlled trial the investigators aim to compare the OAGB and the EPGB in terms of percentage total weight loss (%TWL) 1 and 3 years postoperatively, postoperative complications and comorbidity remission in…
The primary objective is to evaluate the effect of continuing GLP-1 RA on gastric volume after standard preoperative fasting in patients using GLP-1 RA for >12 weeks. Additionally, we will evaluate the effect of withholding GLP-1 RA on…
The aim of this trial is to investigate the safety and efficacy of an adaptive anastomosis using the C-REX RectoAid Cath following elective anterior resection for sigmoid or proximal rectal cancer, or premalignant lesions not amenable tot endoscopic…
Primary Objective: The primary objective is to assess the effectiveness of HVB-assisted therapy (HV-BAT) in reducing self-reported SA.Secondary Objectives: The secondary objective is to assess the effectiveness of HVB-assisted therapy (HV-BAT) in…
Primary Objective: To study the association between muscle characteristics (contractile, morphological,biochemical, and histological) and the response to high- and low-load exercise training on muscle strength in patients with rheumatoid arthritis (…
Primary: To compare the efficacy of epigenome-guided treatment selection to usual standard of care (SOC) treatment selection for inducing clinical remission and endoscopic response at Week 26 in participants with active CD.Secondary:-To explore the…