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Adaptive anastomosis for anterior resection in sigmoid and proximal rectal cancer or premalignant lesions: a multicentre non-randomised clinical effectiveness trial (ADAPT)

The aim of this trial is to investigate the safety and efficacy of an adaptive anastomosis using the C-REX RectoAid Cath following elective anterior resection for sigmoid or proximal rectal cancer, or premalignant lesions not amenable tot endoscopic…

Online Breathwork-Assisted Therapy for Social Anxiety

Primary Objective: The primary objective is to assess the effectiveness of HVB-assisted therapy (HV-BAT) in reducing self-reported SA.Secondary Objectives: The secondary objective is to assess the effectiveness of HVB-assisted therapy (HV-BAT) in…

Are muscle characteristics associated with the effect of exercise training on muscle strength in rheumatic diseases and sarcopenia? - an explorative study
The Care for Muscle (C4M) Study

Primary Objective: To study the association between muscle characteristics (contractile, morphological,biochemical, and histological) and the response to high- and low-load exercise training on muscle strength in patients with rheumatoid arthritis (…

A PrOspective RandoMIsed Study of Treatment Selection Based on Epigenetic Markers Versus Standard of Care Treatment Selection in Adults With

Primary: To compare the efficacy of epigenome-guided treatment selection to usual standard of care (SOC) treatment selection for inducing clinical remission and endoscopic response at Week 26 in participants with active CD.Secondary:-To explore the…

Safety and efficacy of nadroparin in children: an observational study.

Therapeutic nadroparin administration:Primary objective: To develop evidence-based dosing regimens of nadroparin for children in different age groups by means of the objectification of the PK/PD of nadroparin.Secondary objective: 1) Investigate the…

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in
Patients with Advancing Heart Failure (TEAM-HF)

The TEAM-HF trial consists of two arms: a Randomized Arm and a Single Arm Registry.TEAM-HF Randomized Arm: The objectives of the Randomized Arm are two-fold: 1) Demonstrate improvement in survival when non-inotrope dependent advanced HF patients are…

Autonomy-enhancing therapy for inpatient eating disorder care

Primary Objective: To evaluate the feasibility and acceptability of AET in the inpatient treatment of AN through qualitative feedback from patients and clinicians.Secondary Objective(s): To identify autonomy-related interventions currently already…

Change in task-related oxygen uptake after bronchoscopic lung volume reduction with endobronchial valves

To investigate the change in exercise physiology during daily activities after EBV treatment.

OMIT trial: omitting therapeutic lymph node dissection in patients with stage IIIB/C melanoma and major pathological response in the index lymph node after neoadjudvant immunotherapy

To investigate whether TLND can be safely omitted in patients with macroscopic resectable stage III (B/C/D) melanoma achieving an MPR within the ILN upon neoadjuvant treatment with nivolumab in combination with ipilimumab.

Thermoradiotherapy for locally Advanced head and Neck Cancer patients - A phase I dose finding study (TANCA-I)

Primary Objective: To determine the recommended phase II dose (RP2D) of thermoradiotherapy in LA-HNSCC patients. Secondary Objective(s): • Evaluate the Local control, Disease Free Survival and Overall Survival of thermoradiotherapy. • Objective…

A pilot feasibility study of Dose dE-eScalaTion IN prostATe radIOtherapy with empty bladder usiNg the
MRL - DESTINATION 1B(ladder)

To develop a 5 fraction de-escalated dose SBRT protocol potentially capable of reducing side effects intended for prostate cancer patients with empty bladder

Implementation of a home-based computerized cognitive rehabilitation program for patients with acquired brain injury

Patients with ABI follow a multidisciplinary rehabilitation program. This program is very intensive and also requires a lot from loved ones. The burden can be reduced by partly delivering the program from home.The aim of this project is to implement…

The DRAGON-PLC trial: An international multicentre randomised controlled trial to compare combined Portal and Hepatic Vein Embolisation (PVE/HVE) with PVE alone in patients with primary liver cancers.

To evaluate the effect of combined PVE/HVE compared to PVE alone on resectability and overall survival in patients with primary liver cancers.

The influence of female sex hormones on the subjective and cognitive response to cannabis

Primary Objective: To assess the acute subjective drug effects (good/bad drug effect, drug liking/wanting, anxiety), cognition (attention, working memory, information processing speed, verbal memory, verbal fluency, motor inhibition), and…

HIPPI shoulder - Hip-allograft In Proximal humerus fractures versus Plate Implantation alone: a randomized controlled trial

The aim of this RCT is to examine the differences in functional, clinical, and radiological out-comes, between LCP fixation alone and femoral allograft augmentation in addition to LCP. Ultimately, the purpose is to optimize treatment strategies and…

Comparison of outcome in cLEft palate surgery After different types of surgical Repair techniques

The aim of this study is to compare the outcomes after three different surgical techniques, namely straight line closure, Z-plasty closure and closure using cheek flaps, with regard to speech outcomes and postoperative complications by means of a…