15 results
The primary objective of the second part of the study, which is the focus of this application, is to perform a comparative analysis of the cognitive profile and MRI outcomes of DMD/BMD patients.
Primary Objective: To investigate longitudinal variation of blood-based biomarkers, their integration with disease severity, comorbidities, their association with standard care and characterization of adequate and inadequate responders to standard…
The main objective of this study is to characterize the pathogenic B cells and the auto-antibodies that are responsible for causing the myasthenic or pemphigus syndromes. The secondary objective is to generate recombinant antibodies based on the…
Primary objective: To evaluate the role of existing and novel quantitative biomarkers in understanding the heterogeneity in the Parkinson*s phenotype (i.e. rate of progression, cognitive and neuropsychiatric impairment and motor dysfunction) and…
This study aims to be the first to visualise changes in both clitoris and pelvic floor musculature following testosterone administration and to explore how these changes relate to sexual function. The primary objective of this observational study is…
Primary Objective: The central focus of the 7T study is to investigate the influence of sleep and its various stages, particularly slow wave sleep, on CSF mobility within perivascular spaces.The primary aim of the 3T experiment is to explore the…
The primary objective is to explore the effect on Donning and Doffing of REACTION and their subsystems (ABLE REGAIN and GABLE CORE) in individuals with neurological disorders. The secondary goals include: 1. To explore the effect of REACTION and…
Our primary objective is to collect normative reference values in typically healthy developing children, aged 0 - 18 years, for EEG in combination with ERP and eyetracking, and OCT measurements (For details see also paragraph 5.1).
The aim of this study is to determine whether this smart wristband can actually support patients and their parents in managing the consequences of hypothalamic dysfunction. We will investigate what kind of support patients, parents, or caregivers…
The overarching objectives of this proposal are: 1) To evaluate the effect of noradrenergic modulation on type I potentials in wakefulness (vertex potentials), and NREM sleep (vertex sharp waves, K-complexes) and on dreaming in NREM sleep; 2) To…
To assess the feasibility of the Virtual Ward in six pre-defined sub-cohorts of non-elective hospitalized patients within the current Dutch healthcar
Primary Objective: To explore the computations which occur in the brain which occur in visual disorders and determine how these differ from healthy controls. Specifically, we expect that the overall sensitivity (area under the curve) which reflects…
The current trial aims to assess and validate atrial fibrillation detection and monitoring by the Corsano CardioWatch 287-2 in a remote setting across multiple international centres. By: a) To compare episodes of atrial fibrillation across 30-second…
Primary Objective: to assess brain kinetics of glutamate, GABA and dopamine and the associated functional connectivity of the mesocorticolimbic circuit during the absorption and elimination phase of JWH-018, as compared to the control condition.…
The aim of this study is to investigate whether the transfer of antibodies from mother to infant is less effective in infants with intrauterine growth restriction (FGR) compared to term-born infants without intrauterine growth restriction or who are…