81 results
The main objective of this study is to observe current AE treatment strategies and the treatment response of these strategies after 2 weeks in several hospitals. Secondary objectives are (1) to measure effect treatment on FeNO, eosinophils and…
To investigate the effect of nutritional prehabilitation on adverse events in patients with locoregionally advanced head and neck cancer, with low to medium risk of malnutrition and with radiological sarcopenia. To evaluate its effect on patient-…
The purpose of the VISABL-AFL study is to demonstrate safety and efficacy of RF ablation of type I atrial flutter (AFL) with the Vision-MR Ablation Catheter 2.0 in conjunction with the Osypka HAT 500 RF generator and irrigation pump. Data collected…
Primary ObjectiveTo assess the safety, feasibility and frequency of relapsing P. vivax PvW1 infection after experimental sporozoite-administered Controlled Human Malaria Infection (CHMI)Secondary ObjectivesTo assess the immune response to primary…
The goal of the current study is to evaluate both the feasibility and validity of the Corival ALT prototype for exercise testing in patients with lower limb deficits.
To investigate the effect of multiple sessions of whole body NMES, with or without consecutive protein intake, on muscle protein synthesis.
The aim of this study is to characterize the internal 1 µm polystyrene microplastic (PS-MP) exposure in various human tissues in healthy volunteers. For this, the uptake and excretion of a single microdose of 1 µm [14C]-labelled PS-MP is…
The main objective of the study is to investigate the effect of inclusion in the LLA on E33 notifications. Secondary objectives include investigating the effect of inclusion in the LLA on criminal behaviour (arrests, recidivism and risk of…
The objective of this CPS is to establish the clinical performance of F1CDx as a companion diagnostic (CDx) for AZD0022 in patients with NSCLC, CRC, or PDAC with a KRASG12D mutation. This CPSP will be executed in combination with the clinical trial…
The main (primary) objective is to study the influence of sex on the pharmacokinetics (PK) of metoprolol in patients after CABG with heart valve surgery and patients with a STEMI/NSTEMI who are prescribed a standard dosage of metoprolol as part of…
Primary Objective: To determine how exposure to +5Gz forces affects small airway function when breathing ambient air (21% oxygen) and oxygen enriched air (60% oxygen) , without the breathing component of the AGSMSecondary Objective: To explore the…
To compare L-MILP with R-MILP for benign and pre-malignant lesions of the pancreas in high-volume centers, regarding:1. Peri- and postoperative outcomes in terms of COMPOS-panc left score, for non-inferiority2. Total hospital-related costs, for…
To study anti-SARS-CoV-2 antibody-mediated inflammatory responses by macrophages in individuals with obesity.
Why wait? (Cost)effectiveness of an online transdiagnostic therapy for patients and their loved ones
In the current study, we will analyze the (cost)effectiveness of an online, transdiagnostic positive psychology eHealth intervention for patients waiting for psychological out-patient treatment and their relatives. We expect that this intervention…
Primary objective: To investigate the effects of fully inhibiting type 2 inflammation on esophageal mucosal barrier function and inflammation in adult EoE patients. Secondary objective: To evaluate the effect of type 2 inflammation and the IL4 /…
This study aims to evaluate and compare the long-term outcomes of tissue-level and bone-level single implants in the posterior region of the mandible or maxilla in patients with adequate bone for implant placement, with or without prior bone…
The primary objective is to investigate in overweight or obese older adults the effect of daily protein supplementation for two weeks with either a plant-derived protein or an animal-derived protein on vascular function and insulin-sensitivity in…
To elucidate whether reducing glycemic variability with hybrid closed-loop therapy inhibits the inflammatory response (e.g. leukocyte phenotype, cytokine production, inflammatory proteins) in people with T1DM. Our secondary objectives are to…
The main objective is to investigate if splintless approach improve the surgical accuracy of MMA for OSA. The secondary objectives are to assess the effect of splintless MMA on duration of surgery, blood loss, adverse events, respiration function,…
Primary objective: To establish a controlled human infection model for C. difficile which is safe, well tolerated and results in microbiological and clinical endpoint in ideally >=70% of volunteers. Secondary objectives:- Assess colonisation…