83 results
The main objective of this study is to characterize the pathogenic B cells and the auto-antibodies that are responsible for causing the myasthenic or pemphigus syndromes. The secondary objective is to generate recombinant antibodies based on the…
The aim of the 100-plus Study is to identify moleculair and environmental constellations that maintain cognitive healthduring extreme aging.
The primary aim of this study is to determine the added value of third look DLS to detect PM at a clinically occult stage following a negative second look DLS.
Primary Objective: To determine the recommended phase II dose (RP2D) of thermoradiotherapy in LA-HNSCC patients. Secondary Objective(s): • Evaluate the Local control, Disease Free Survival and Overall Survival of thermoradiotherapy. • Objective…
To develop a 5 fraction de-escalated dose SBRT protocol potentially capable of reducing side effects intended for prostate cancer patients with empty bladder
To assess the feasibility of using the developed medication management centre to empower polypharmacy patients, thereby improving drug safety. Secondary objectives are to explore if the tool is able to identify patients at risk for a drug-drug-gene…
The primary objective of phase 1 is to validate a new ELISA measurement that can determine hIAPP oligomers reliably in plasma, and of phase 2 is to correlate pathogenic oligomer hIAPP (in plasma and skin) with pain and sensory disturbances in CIAP…
Patients with ABI follow a multidisciplinary rehabilitation program. This program is very intensive and also requires a lot from loved ones. The burden can be reduced by partly delivering the program from home.The aim of this project is to implement…
Primary Objective: to assess brain kinetics of glutamate, GABA and dopamine and the associated functional connectivity of the mesocorticolimbic circuit during the absorption and elimination phase of JWH-018, as compared to the control condition.…
To evaluate the effect of combined PVE/HVE compared to PVE alone on resectability and overall survival in patients with primary liver cancers.
The primary aim of this study is to determine the causal relationship between the accumulation and inflammation of perivascular adipose tissue (PVAT) and insulin-stimulated glucose uptake in skeletal muscle, measured using dynamic PET-CTA, in…
The primary objective of this Clinical Performance Study is to utilize the Device for performance evaluation to detect HLA-A Locus alleles as part of the eligibility criteria for patients to receive an experimental medicinal product under the DS2243…
Primary Objective: To assess the acute subjective drug effects (good/bad drug effect, drug liking/wanting, anxiety), cognition (attention, working memory, information processing speed, verbal memory, verbal fluency, motor inhibition), and…
The aim of this RCT is to examine the differences in functional, clinical, and radiological out-comes, between LCP fixation alone and femoral allograft augmentation in addition to LCP. Ultimately, the purpose is to optimize treatment strategies and…
The aim of this study is to investigate whether the transfer of antibodies from mother to infant is less effective in infants with intrauterine growth restriction (FGR) compared to term-born infants without intrauterine growth restriction or who are…
To assess the feasibility of the Virtual Ward in six pre-defined sub-cohorts of non-elective hospitalized patients within the current Dutch healthcar
To predict the progression of CKD with diuretic testing.
The aim of this study is to compare the outcomes after three different surgical techniques, namely straight line closure, Z-plasty closure and closure using cheek flaps, with regard to speech outcomes and postoperative complications by means of a…
The primary aim of this study is to investigate whether a canal wall up (CWU) tympanomastoidectomy with obliteration of the mastoid and paratympanic or epitympanic spaces reduces cholesteatoma recurrence and residual rates compared to the same…