21 results
The aim of the present study is identifying CEBA profiles in pwMS and subsequently developing a feasible screening instrument allowing quick identification of CEBA profile and subjective burden of pwMS in clinical practice, providing a suitable…
The primary objective of this study is to describe and to quantify the change in cardiac mechanoenergetics, expressed by PVL monitoring (reflected by the parameters stroke work, potential energy and pressure-volume area), in patients undergoing…
We aim to study the rate of developing a biopsy-based diagnosis of high-grade dysplasia (HGD) and EAC in BE patients in a prospective cohort of 204 BE patients at high risk of progression (i.e. after endoscopic removal of visible lesions containing…
The goal of the present study is to evaluate whether voice or capnometry, alone or in combination with other (non-invasive) biomarkers, can be used to detect emphysema predominant COPD phenotype (>=25% emphysematous lung tissue).
To evaluate the efficacy and safety of tucatinib in combination with trastuzumab and mFOLFOX6 in comparison to mFOLFOX6 given with or without either bevacizumab or cetuximab as first-line (1L) treatment in adults with HER2 positive (HER2+)…
The objectives of the study are:• To understand the phenotypic heterogeneity and phenotype/genotype correlation and natural history of ALSP.• To develop and evaluate biomarkers for assessing disease progression in patients with ALSP.• To create the…
To develop and test new MRI sequences that enable new imaging contrasts and enable depiction of tissue properties that can not be depicted with current techniques.
Primary objectives: This study is two-fold and, therefore, has two primary objectives:1. Investigating the diagnostic accuracy of CLE (Cystoflex*F probe) during flexible cystoscopy for diagnosis and grading of urothelial carcinoma of the bladder.2.…
1, Quantify and compare vascular and structural parameters obtained from AO-FIO, OCTA, OCT, and CFP in both healthy controls and glaucoma patients; 2, Investigate the correlation between these parameters and assess the additional value of vascular…
Primary objective:What is the incidence of an unsafe swallow situation (PAS score >= 6) after decannulation in ICU patients who had a safe swallow situation with a tracheal cannula prior to decannulation (PAS score < 6)?Secondary…
Primary objective: - To study the diagnostic accuracy of PCCT (± CT-derived fractional flow reserve [FFRct]) as compared to the reference standard ICA (± FFRinv) in the NSTE-ACS population referred to the UMCG. Secondary objectives: - To study the…
The aim of this study is to better understand the relation between cognition, sensory functions and motor control for speech in older age. Thereby, we strive for improved speech-based discrimination of typical aging from neurodegenerative declines.
Our overall aim is to develop mid-field MRI systems for low-threshold, extramural service to GP practices that can contribute to making healthcare more sustainable. In this study we want to perform the first steps towards this general aim. On one…
Intra-arterial pressure measurements are currently the most promising tool to guide clinical decision making in patients with suspected CMI. Implementation of pressure measurements could result in major improvements in quality of life by tailoring…
To determine the proportion of travelers and migrants diagnosed with chronic schistosomiasis as per each centre*s routine assessment, who have active infection at presentation (as assessed and classified by composite reference standards integrating…
The primary objective of the study is to determine the technical feasibility of ctDNA detection in small volumes of capillary blood. This will be investigated through determining the agreement between ctDNA measurements in venous (standard blood…
The primary objective of this study is to evaluate the diagnostic value of preselected salivary biomarkers known to be significantly elevated in individuals with obesity. This includes assessing their sensitivity and specificity to ensure their…
EUGENIE aims to bridge the knowledge gap. As up till now disease stage was the most important prognostic factor, we aim to improve the molecular risk classification system by integrating the disease stage into the molecular subgroups. As a first…
Objectively evaluate the chewing ability with the mixing ability test and evaluation of complaints with validated questionnaires, compared to gender and aged matched control group.
The question of this project is: can we demonstrate and exclude exon 3 mutations in CTNNB1 by analyzing circulating DNA from patients with a liver adenoma? The work plan is as follows: we include patients with a liver adenoma of at least 3 cm in…