23 results
OpACIN-neo:Primary objectives: - To compare safety (immune related adverse events during the first 12 weeks) of three different neo-adjuvant combination schemes of ipilimumab + nivolumab - To compare radiological and pathologic response rates at…
The primary objective is to examine whether changes over time in monitoring measures of cognition and behavior are associated with functional outcomes in pediatric oncology groups. Additional objectives are to examine trajectories, risk factors, and…
Primary objective:- To investigate if neo-adjuvant combination of talimogene laherparepvec and nivolumab will achieve a pathologic response rate of 45% complete responses (either *pathological complete response (pCR)* or *pathological near complete…
Primary Objective:1. To validate the HLA-DQ typing in blood taken by a fingerprick; to make it feasible in the regular Preventive YHCCs organization.2. To establish the feasibility of HLA-DQ2/8 typing in the active case-finding at the Preventive…
The objective of this study is to assess the clinical effectiveness of the PatientCoach mHealth app with and without home monitoring devices on sustained asthma control after AACT, in patients with severe or uncontrolled asthma.
To evaluate in SSc patients with low risk for disease progression 1) whether assessment in an outpatient clinic setting is an acceptable alternative for evaluation in the Care Pathway. Outcome parameters we will evaluate include 1) health care…
Objective: To evaluate the usability (feasibility) of the recently developed tool 'NutriProfiel focused on athletes' so that opportunities can be explored for further improvement and implementation in practice.
Primary Objective The primary objective of this study is to compare the 3-year overall survival of stage III NSCLC patients during follow-up surveillance with 18F FDG PET/CT versus follow-up with conventional CT surveillance. Secondary…
The aim of this project is to test the hypothesis that symptom-free days (SFDs) of children with preschool wheezing can be increased using Luchtbrug Junior, while reducing regular outpatient visits by 50%.
1. to monitor how seroconversion rates of SARS-coV progress during the COVID-19 pandemic in health care workers with direct contact with COVID-19 suspected or confirmed patients compared to a control group without this exposure, and 2. assess the…
The primary objective is to determine whether implementation of a best-practice protocol focused on antimicrobial stewardship in Dutch hospitals is non-inferior compared to standard care on mortality and major complications in patients with acute…
Primary objective:Can a personalised lifestyle intervention (LIFE-ID intervention) support healthcare professionals in achieving effective and long-term lifestyle improvement (increased physical activity) for adults with ID to improve their&…
We aim to assess the effects of two approaches of ACP (detailed advance treatment orders versus global goal setting and coping based) on wellbeing of persons with dementia. In addition, we will assess effects on decisional conflict, self-efficacy to…
The objective of this study is to determine what the differences are between care as usual and care where a seizure detection device is used in addition to care as usual. Specifically, this study will compare the number of missed and correct visits…
To assess whether adjuvant chemotherapy can be safely omitted in patients with pathological stage I (pT1a/b/cN0) TNBC and a high sTIL score (defined as >=50% for patients <40 years at the time of TNBC diagnosis; >=75% for…
Determine AYA*s experiences and needs related to FP(C) and follow-up care after FP(C) (Q1); determine the number of AYAs pursuing to conceive and their fertility and obstetric outcome(s) after FP(C) after gonadotoxic treatment (Q2); determine…
Objective 1: To assess the effect of implementation of a dashboard, with (near) real-time data feedback of risk stratification tools and care processes, on relevant clinical outcomes (in-hospital mortality, ED-LOS, admission rate) and discrepancy…
This feasibility study will now evaluate its use during regular visits, gathering feedback from parents and YHCP, along with user data from the digital tool.
Objective 1: To assess knowledge, attitude health-care professional satisfaction andperceived barriers and facilitators of use and implementation by health care professional inthe ED.Objective 2: To assess process of care and outcome indicators…
This study aims to examine how senior year medical residents from different specialties in the Netherlands understand and apply the legal framework for reporting possible child maltreatment. Moreover, we aim to understand the threshold to report a…