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PreventPAP trial

To compare postamputation pain (phantom limb pain and residual limb pain) one year postoperatively in patients receiving a lower extremity amputation with standard neurectomy versus those who received targeted muscle reinnervation.

Defeating Fear with Exposure therapy delivered by mental health nurses in primary care for Anxiety Disorders in older adults - a cluster-randomized controlled trial

The primary objective of this study is to evaluate the (cost-)effectiveness of ET for late-life anxiety disorders delivered by trained MHNs in primary care, in terms of anxiety and quality of life, compared to UC. UC is not restricted, and the GP…

AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion

The purpose of the pivotal study is to determine the safety and efficacy of IMPEDE-FX RapidFill for increasing the percentage of subjects with shrinkage of the abdominal aortic aneurysm sac when used as an adjunct to on-label EVAR stent graft…

The role of a nutritional formulation containing caprylic acid and omega 3 fatty acids in promoting skeletal muscle function recovery to damaging exercise in healthy, young volunteers

To assess the impact of a nutritional formulation containing caprylic acid and omega 3 fatty acids on skeletal muscle function recovery from damaging exercise.

Indoor air quality, temperature and cognitive performance

This study aims to examine the interactive effect of indoor air quality and temperature on human cognitive performance. The main research objective of this study is to examine how poor indoor air quality in terms of 900 ppm CO2 compared to 3,000 ppm…

A web based cognitive behavioral therapy that addresses gender
dysphoria, gender minority stress and suicidality among gender minority youth. A Randomized Control Trial

Research question:To what extent is a web-based, Cognitive Behavioral Therapy (CBT) specially designed for young gender diverse youth in the Netherlands, an effective treatment to reduce their suicidality? Are there gender, sex assigned at birth,…

LIGHT (Lifestyle Intervention in the memory clinics of General and academic Hospitals Trial): Secondary prevention of dementia in memory clinics: implementation and (cost-) effectiveness of an integrated lifestyle intervention

The primary objectives are to examine both the (cost-)effectiveness of an innovative 1-year lifestyle intervention on lifestyle change measured by the validated Lifestyle for Brain Health Score (LIBRA) in older adults with a subjective cognitive…

REWARM Study - Renal Ex vivo Warm Advanced Resuscitation through Machine perfusion - a multi-center randomized controlled trial

The primary objective is to compare post-transplant outcome after a 6 hour period of NMP immediately prior to transplantation following standard hypothermic machine perfusion (HMP), to outcome after standard HMP alone of 50+ deceased-donor kidneys.…

The role of the adrenergic system in hypoglycaemia induced inflammatory response in people with type 1 diabetes and people without type 1 diabetes-RAID-II

To examine the effect of adrenergic inhibition on the hypoglycaemia induced inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by performing a hyperinsulinaemic hypoglycaemic glucose clamp alongside infusion of α-ARA…

The NUTRIOME study: Precision nutrition and postprandial immune response

To acquire metabolic health data from three dietary challenge meals for thedevelopment of an algorithm for personalised dietary advice, and subsequentlytest the effectiveness of this personalised dietary advice compared to ageneral healthy diet…