24 results
Primary objective:- To investigate if neo-adjuvant combination of talimogene laherparepvec and nivolumab will achieve a pathologic response rate of 45% complete responses (either *pathological complete response (pCR)* or *pathological near complete…
The primary objective is to examine whether changes over time in monitoring measures of cognition and behavior are associated with functional outcomes in pediatric oncology groups. Additional objectives are to examine trajectories, risk factors, and…
OpACIN-neo:Primary objectives: - To compare safety (immune related adverse events during the first 12 weeks) of three different neo-adjuvant combination schemes of ipilimumab + nivolumab - To compare radiological and pathologic response rates at…
To evaluate in SSc patients with low risk for disease progression 1) whether assessment in an outpatient clinic setting is an acceptable alternative for evaluation in the Care Pathway. Outcome parameters we will evaluate include 1) health care…
Primary Objective:1. To validate the HLA-DQ typing in blood taken by a fingerprick; to make it feasible in the regular Preventive YHCCs organization.2. To establish the feasibility of HLA-DQ2/8 typing in the active case-finding at the Preventive…
To investigate the effect of FCR during hospital stay, accompanied by FICare, on parental stress at discharge in parents of preterm (born before 37 weeks of gestational age) or ill (for instance with sepsis or small for gestational age) infants…
The objective of this study is to assess the clinical effectiveness of the PatientCoach mHealth app with and without home monitoring devices on sustained asthma control after AACT, in patients with severe or uncontrolled asthma.
We aim to assess the effects of two approaches of ACP (detailed advance treatment orders versus global goal setting and coping based) on wellbeing of persons with dementia. In addition, we will assess effects on decisional conflict, self-efficacy to…
1. to monitor how seroconversion rates of SARS-coV progress during the COVID-19 pandemic in health care workers with direct contact with COVID-19 suspected or confirmed patients compared to a control group without this exposure, and 2. assess the…
Objective: To evaluate the usability (feasibility) of the recently developed tool 'NutriProfiel focused on athletes' so that opportunities can be explored for further improvement and implementation in practice.
Primary Objective The primary objective of this study is to compare the 3-year overall survival of stage III NSCLC patients during follow-up surveillance with 18F FDG PET/CT versus follow-up with conventional CT surveillance. Secondary…
The objective of this study is to determine what the differences are between care as usual and care where a seizure detection device is used in addition to care as usual. Specifically, this study will compare the number of missed and correct visits…
The primary objective is to determine whether implementation of a best-practice protocol focused on antimicrobial stewardship in Dutch hospitals is non-inferior compared to standard care on mortality and major complications in patients with acute…
Primary objective:Can a personalised lifestyle intervention (LIFE-ID intervention) support healthcare professionals in achieving effective and long-term lifestyle improvement (increased physical activity) for adults with ID to improve their&…
This study will evaluate the effectiveness and implementation process of TMD-COMFORT, a near-real-time pain management dashboard, in the NICU of Erasmus MC-Sophia Children*s Hospital.
To develop a tailored care pathway for RDPC that ensures effective use for pregnant women in vulnerable circumstances.
Determine AYA*s experiences and needs related to FP(C) and follow-up care after FP(C) (Q1); determine the number of AYAs pursuing to conceive and their fertility and obstetric outcome(s) after FP(C) after gonadotoxic treatment (Q2); determine…
To assess whether adjuvant chemotherapy can be safely omitted in patients with pathological stage I (pT1a/b/cN0) TNBC and a high sTIL score (defined as >=50% for patients <40 years at the time of TNBC diagnosis; >=75% for…
The aim of this project is to test the hypothesis that symptom-free days (SFDs) of children with preschool wheezing can be increased using Luchtbrug Junior, while reducing regular outpatient visits by 50%.
Objective 1: To assess the effect of implementation of a dashboard, with (near) real-time data feedback of risk stratification tools and care processes, on relevant clinical outcomes (in-hospital mortality, ED-LOS, admission rate) and discrepancy…