44 results
Primary objectivesFor part A of the study: -To determine the feasibility of Clofarabine when given at three possible dose levels together with standard induction cycles I and II in patients with AML/ RAEB with IPSS>=1.5 in a prospective…
At the moment it is unknown which radiomics features are robust against variations in image characteristics. The objective of this study is to check the robustness of radiomics features, and to investigate wheter specific pre- and postprocessing…
The primary objective of this study is to estimate the efficacy of SABR for primary RCC.
To develop a feasible assessment protocol to quantify the impaired upper extremity function in terms of muscle weakness, spasticity, synergy and viscoelastic properties around the elbow.To evaluate the reliability (test-retest, measurement error)…
The overall aim of this study is to demonstrate increase of tumor-infiltrating CD8+ T cells in non-small cell lung cancer during neo-adjuvant treatment with durvalumab (MEDI4736).
Is there a difference in morphological and vascular placental development between ART and naturally conceived pregnancies?
- Primary study objective: To demonstrate the superiority of the ablative microboost dose schedule regarding 5-year biochemical no evidence of disease rate compared to the current standard of care.- Secondary study objectives: Establish and compare…
1A) To implement a screening-protocol for HIV related co-morbidities and their risk factors, based on multidisciplinary expert consultation, in a large HIV outpatient clinic and among an HIV-uninfected control group.1B) To assess the prevalence and…
This intervention study investigates the effectiveness, costs and cost-effectiveness of a protein-enriched diet and resistance exercise training for 3 months on bone and muscle health, and quality of life in older adults recovering from an acute…
Establishing efficacy and safety of the electrodes and implantable pulse generators (IPGs), which are used for deep brain stimulation (DBS) in patients with obsessive-compulsive disorder (OCD).
To determine the safety, feasibility, and tolerability of adding PIPAC with oxaliplatin (92 mg/m2) to systemic chemotherapy in patients with isolated PM from CRC.
The purpose of this study is to assess short-term and the long-term safety and efficacy of oral ZPL389 (30 mg once daily (o.d.) and 50 mg o.d.) when used concomitantly or intermittently with topical corticosteroid (TCS) and/or topical calcineurin…
Comparison of hearing preservation and outcome of two fundamentally different cochlear implants designs (LW or PM) and the two most used surgical approaches (RW or CO). Secondly, asses the structure preservation (i.e., scalar position) of each…
To determine the accuracy of US for detecting disease activity in paediatric patients with IBD and to develop an easy-to-use and accurate US-activity index that can accelerate and improve clinical management by reducing the need for gastrointestinal…
Primary objective - To assess the efficacy of q4w x3 i.a. injections of LRX712 in restoring the morphometrics of articular cartilage in the medial femoral condyleSecondary objectives- To evaluate LRX712 and metabolite MAE344 pharmacokinetics in…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with RA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more effective…
Primary Objectives- To objectively quantify the spatial and temporal kinetics of perfusion and wound healing using clinical imaging and evaluations between diabetic wounds before and after endovascular revascularization and between diabetic patients…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with axSpA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more…
We want to investigate what happens to the immune cells during different types of radiotherapy (schedules). With this study, we want to take blood samples from patients during their standard radiotherapy for cancer and determine the effect on immune…
To prospectively validate the safety and efficiency of management according to the YEARS algorithm to safely rule out clinically suspected PE in patients with active malignancy to be compared with `standard' management by CTPA alone in a…