86 results
This current study aims to examine the effects of a 6-week colon-delivered multi-vitamin supplement intervention on cognitive performance and stress levels in military under real-life, stressful working conditions.
To understand the mechanism of action of OA for the treatment of de novo, severely calcified coronary lesions prior to stent placement using optical coherence tomography (OCT) and to assess stent expansion, based on OCT derived minimal stent area (…
Part 1:Primary Objective- To investigate whether repeated dose GRX-917 reduces panic symptoms elicited by an experimental 35% CO2 -induced fear challenge administered in healthy CO2-sensitive subjects. Secondary Objectives- To investigate whether…
The main objective is to determine function/clinical outcome, measured by the NRS-11 score for pain, 3 months after intervention and compare this between the surgery and conservative group. Secondary objectives are functional outcome as measured by…
Primary objectiveThe primary objective is to evaluate whether a standard pre- and postdilatation of the modern DES results in a more optimal stent implantation compared to DS as evaluated by OCT in patients with stable coronary artery disease.…
The objective of this study is to investigate the effect of VR on post-operative pain and anxiety management in cardiac surgery patients undergoing a coronary artery bypass grafting (CABG) procedure.
The primary objective is to investigate if the stress-induced dynamics across stress systems are impaired in patients with CT-related depression compared to non-CT-related depression and healthy controls. The secondary objective is to examine how…
To assess the efficacy of treatment with Endocalyx for chronic heart failure.
Primary objective:- To identify (a combined set of) clinical and non-clinical markers most sensitive to disease progression in Dtuch SCA7 mutation carriers.Secondary objectives:- To quantify the annual change in disease-relevant clinical scales and…
The primary objective is to evaluate whether cyclic daytime enteral feeding can decrease the disruption of circadian rhythms in critically ill patients compared to continuous enteral feeding. Secondary objectives are to evaluate the effect of cyclic…
- To assess the CNS functional effects of OPC-214870 following dosing using Neurocart test battery
Therefore, this feasibility study will evaluate whether the 18F-PSMA PET/CT is capable of MTC lesion detection. Moreover, we will compare its ability to detect MTC lesions with a routinely used PET scan, the 18F-FDG PET. By exploring new tracers in…
The primary objective of this study is to investigate the effects of personalized dietary guidance to increase the intake of fibre-rich foods, as recommended in the Dutch dietary guidelines, on cardiometabolic risk profile in individuals who have…
The aim of this study is to evaluate the predictive capacity of cervical softening and risk of PTB.
1) To study PPG signal characteristics in relation to circulatory arrest in patients with induced circulatory arrest. 2) To construct a PPG-based algorithm for detection of circulatory arrest based on induced circulatory arrest data in patients. 3)…
Primary objective: Investigation of mean peak plantar pressure at the location of the diabetic foot ulcer and at 6 plantar regions of the foot (i.e. hallux, digits, first metatarsal, second to fifth metatarsals, midfoot, and heel) during total…
This study has several objectives, in different (subsequent) study phases:• A1. Optimize and validate the technology of the VD to reach non-inferiority• B1. Demonstrate non-inferior performance and safety of the VD, for CE marking• B2. Demonstrate…
Part A: Determine the performance of using 4D DCE-BCT for tumour staging. Part B: Determine the performance of 4D DCE-BCT in monitoring of treatment response and prediction of final treatment outcome based on early response in patients that undergo…
Primary Objective: to determine the activity rhythm of the SCN in humans with progressive stages of insulin resistanceSecondary Objective(s): to determine the daily rhythm of the peripheral clock in buccal cells in humans with progressive stages of…
Primary objective (after 1 year)- To evaluate the effectiveness of the nurse-led GILL eHealth intervention in patients with serious mental illnessSecundary objectives (after 1 year)- Improve metabolic syndrome severity- Improve fitness, physical…