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Iodine Mapping using Subtraction in Pulmonary Embolism Computed Tomography versus Dual Energy Computed Tomography.

To evaluate image quality and accuracy of detection of perfusion defects associated with pulmonary pathology on iodine maps of the lung that are created by two different CT techniques: 1. A standard of care CTPA with DECT and 2. A new technique that…

Near Infrared Spectroscopy Monitoring of Acute Ischemic Stroke Patients

Objective 1: To prospectively evaluate the utility of C-FLOW monitor to examine status of regional CBF and reperfusion in patients presenting with acute anterior circulation ischemic stroke syndrome. Objective 2: To assess the feasibility,…

Arterial stiffness, Blood Pressure and Cardiac output study; ABC-study;A Prospective, Multidisciplinary study of arterial stiffness measures in patients treated for aortic aneurysms in relation to blood pressure and cardiac output

Zie document PROTOCOL SYNOPSIS ABC study

The use of Rienso, an ultrasmall superparamagnetic particle of iron-oxide, as a MRI contrast agent to image inflammation in the atherosclerotic plaque.

In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.

Study to identify the genetic variations associated with phantom limb pain

The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…

Silent MR Angiography (MRA) of intracranial and extracranial carotid arteries.

Test the optimized MRI sequences/technology against CTA as gold standard, in terms ofimage quality, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), speed, and accuracy/reproducibility of extracted quantitative parameters.

Optimalization of a new 3 tesla Magnetic Resonance Imaging protocol to visualize the aorta

optimization of a new 3 Tesla Magnetic Resonance Imaging protocol for imaging of the aortic vessel wall in order to enhance the identification of individuals at highest risk of developing clinically manifest atherosclerosis

A reproducibility study of novel noninvasive multimodal imaging techniques in atherosclerosis in healthy and cardiovascular diseased subjects

Primary Objectives:A. To assess the reproducibility and variability (interscan, intra- and interreader) of novel (DCE-)MRI techniques to measure vessel wall dimensions, wall shear stress and vessel wall permeability in healthy and cardiovascular…

Reproducibility of the carotid artery vasoreactivity test

To examine the hour-to-hour and day-to-day reproducibility of the CAV-test in young and older humans

Reade Gout cohort
Cardiovascular risk & management in gout patients

The main objective of this study is to assess the prevalence cardiovascular disease and the prevalence of risk factors for cardiovascular disease in patients with gout, and to quantify the risk for cardiovascular disease in patients with gout. The…

Is there a role for duplex ultrasound in patients with a clinical suspicion of temporal arteritis?

Determining the role of duplex ultrasound in patients with a clinical suspicion for temporal arteritis.Determing the sensitivity, specificity, negative predictive value and positive predictive value of duplex ultrasound in patients with a clinical…

Patients with DVT on unusual places and/or < 45 years of age

Frequency of PNH in a selection of patients with DVT. In several publications PNH has been described especially in patients with DVT and younger than 30 years of age and/or with DVT on unusual places.

Validation of an Oesophageal Doppler Cardiac Output Monitor (ODM) versus a Transpulmonary Thermodilution Cardiac Output Monitor (PiCCO).

Goal of our study is to compare the CO measuments by the Oesophageal Doppler Monitor (ODM, Cardio Q) with the TPTD technique (PiCCO) and to determine reliability of the ODM in absolute CO values and as a trend monitor. A validation study comparing…

Incidence of migration and thrombus formation of umbilical venous catheters in infants

Primary objective: to determine the incidence and location of thrombi in the umbilical venous catheter route during and after umbilical catheterization and in the same route in infants without umbilical catheters. Secondary objectives:A. to…

Cerebrovascular manifestations of vascular Amyloid deposition in HCHWA-D | An assessment of the cerebrovascular reactivity in Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D) patients using Magnetic Resonance Imaging and transcranial Doppler.

The primary objective for this study is to evaluate the cerebrovascular reactivity of HCHWA-D patients:1. To compare the (autoregulatory) function of small brain vessels in HCHWA-D patients with matched controls using the cerebrovascular reactivity…

The assessment of the Plaque At RISK by non-invasive (molecular) imaging and modelling (ParisK): Prospective clinical study for diagnosis efficacy for high risk plaque and stroke.

The main objective is to show whether imaging characteristics assessed at baseline can predict clinical events in patients with a 30-69 % symptomatic carotid stenosis.

Pilot study to asses the dependence of skin autofluorescence (SAF) on skin color
and skin tissue characteristics in humans with dark skin

Assess feasibility of development of skin colour independent assessment of skin AGE accumulation by measurement of skin autofluorescence in persons with dark skin

Thrombosis and paroxysmal nocturnal hemoglobinuria clones

The goal is to investigate wether a PNH clone could be the cause of an unexplained thrombosis. In the population of patients with unexplained thrombosis a PNH clone may be the cause.The goal is to investigate whether the prevalence of PNH clones is…

Characterization of ascending aortic flow patterns and vessel wall in patients with aortic valve stenosis before and after surgical valve replacement: a 4D Flow Magnetic Resonance Imaging study.

We aim to i) describe flow patterns and flow-related dynamics in the ascending aorta of patients with aortic valve stenosis, ii) compare these flow parameters before and after surgical aortic valve replacement and iii) compare flow parameters with…

Measurement of local arterial stiffness in the carotid artery in subjects at low and high cardiovascular risk and in patients with recent ischaemic cerebrovascular events.

The main goal of this study is to assess the difference in local pulse wave velocity measured at three different points in the left and right carotid artery in healthy subjects and in patients with symptomatic and asymptomatic carotid plaques. As…