415 results
To gain a better insight into the genetic factors that play a role in the etiology of the thoracic aortic aneurysm with the following specific aims:1. Study of specific geneitc factos that play a role in the pathogenesis of both syndromic and non-…
To evaluate anti-inflammatory effects of statin therapy on vessel wall inflammation by means of FDG PET/CT in AS patients.
In this study, we will assess the reproducibility of the observed dose-dependent inhibiting effect of CK on platelet aggregation.
To establish whether there are differences in monocyte function in patients with high expression levels compared to low expression levels of microRNA *x*.
To understand why statins are able to decrease the risk of developing venous thrombosis, by analyzing whether statins can influence pathways that inhibit coagulation.
In this study we will identify the role of the endothelial GAGs in Na+ and volume homeostasis. Is there a link between the ESL and an individual its susceptibility to Na+-excess?In a following study the Na+ buffering capacity of the intact ESL will…
The overall objective of this project is to assess the interplay between classical risk factors (including lifestyle factors), plasma markers, markers of activated circulating cells and atherosclerosis burden at MR imaging (expressed as aortic…
1. To identify presymptomatic and symptomatic profiles including (early) disease stages and early biomarkers of disease progression and to elucidate pathophysiological mechanisms, we will investigate RVCL patients at different ages (both symptomatic…
To assess the changes in cardiac function and the microcirculatory function in different thyroid states. We aim to identify how thyroid state affects changes in micro and macro hemodynamics.
- To determine the difference in baseline mucosal oxygen saturation measurements and after luminal feeding between patients diagnosed with CGI and healthy subjects. - To determine the difference in baseline mucosal oxygen saturation measurements…
To investigate whether increased aldosterone levels in obese individuals lead to impairment of microvascular function through reduction of NO-availability, and to establish the role of microvasculaire dysfunction in the pathogenesis of salt-…
The main goal of this pilot study is to analyze if using the 7.0 Tesla MRI scanner potential markers predicting aneurysmal rupture (i.e thickness and enhancement of the aneurysmal wall) can be studied in IA patients.
the aim of this study is to compare the impact of an early-CR within 48 hrs. after PPCI to a late complete revascularization >2 weeks after PPCI on LV remodelling in patients with STEMI and multi-vessel disease.
To investigate the innate pro-inflammatory response in young patients (<50 years of age), who suffer from a myocardial infarction. The pro-inflammatory response will be examined by the search for *trained immunity* especially in the monocytes…
To investigate the effect of tourniquet application on the coagulation system in patients undergoing a knee arthroscopy. A finding of more prominent activation of the coagulation system with tourniquet use than with non-use will create an important…
Primary objective: To investigate left ventricular diastolic function in AS-patients compared with osteoarthritis patients. Secondary objectives: To assess the prevalence of valvular heart diseases and conduction disturbances. To assess left…
Primary:2. To investigate the prevalence of vulnerable plaques, i.e. plaques with intraplaque hemorrhage on MRI, in individuals with type 2 diabetes, impaired and normal glucose tolerance and a minimal plaque thickness of 2mm on ultrasonography. To…
To investigate the relationship between C3 and vitamin D in adipose tissue and serum in morbidly obese subjects and in subjects who lost weight due to bariatric surgery.
To determine the effects of renal sympathetic denervation on insulin resistance and muscle sympathetic nerve activity (MSNA) in patients with metabolic syndrome at 3 months after renal denervation.
This study aims to provide a comprehensive assessment of global coagulation parameters in patients with ASC both in hospital and up to 12 weeks after discharge. The results will help define the period at risk for VTE and inform the rationale for…