Search for a trial

A single-center, randomized, double-blind, two-period cross-over study to investigate the effect of rifampicin on the pharmacokinetics of clazosentan in healthy male subjects.

The purpose of the study is to determine how a single administration of rifampicin influences the uptake and breakdown of clazosentan. Furthermore, the safety and tolerability of clazosentan when administered after administration of rifampicin, will…

Valiant Evo International Clinical Trial

The purpose of the Valiant Evo International Clinical Trial is to demonstrate the safety and effectiveness of the Valiant Evo Thoracic Stent Graft System in subjects with a descending thoracic aortic aneurysm (DTAA) who are candidates for…

Deferoxamine in Aneurysmal Subarachnoid Hemorrhage trial

This study investigates the safety and tolerability of deferoxamine use in patients with aneurysma subarachnoid hemorrhage.

First-in-Human for Fiber Optic RealShape (FORS)

The objective of this study is to assess performance of navigation in the arterial tree by using catheters and guidewires that are enabled with FORS-based guidance as add-on to X ray imaging, in aortic and peripheral endovascular procedures.

Randomized, double-blind (for clazosentan), placebo- and moxifloxacin-controlled, 3-way cross-over Phase 1 study to assess the effect of two intravenous doses of clazosentan on the QTc interval duration in healthy subjects

This study aims at investigating potential relevant QT effects of clazosentan at supra therapeutic doses in healthy male and female subjects using a concentration/response analysis approach in compliance with the ICH E14 guidance [FDA 2017].Primary…