469 results
The objective of this study is to determine the feasibility of a RCT that study the effectiveness on mortality and morbidity of cardiovascular preventive medication in people >=75 years without previous cardiovascular disease, without…
Hypothesis: Changes in NIMA over 5 years, measured by repeated NIMA in both a low and a high-risk population, in relation to changes in traditional and new CV risk factors and incidence of CVD will reveal the main determinants of each of the NIMA.…
Correlate plaque characteristics, determined on high resolution 7 Tesla MRI, with cerebral damage ((clinically silent) cerebral (micro) infarcts or bleeds), also seen on 7 Tesla MRI. As gold standard histology of the plaques will be obtained
The primary aim of this study is to investigate if a tight multiple cardiovascular risk reduction program is effective in reducing progression of Intima media thickness progression (subclinical atherosclerosis) in patients with RA compared to usual…
Primary objective: To evaluate whether patients with a prolactinoma have signs of altered vascular function and/or morphology in the retina or sublingual tissues in comparison to healthy controls. Secondary Objectives: 1. To evaluate whether there…
To study the influence of caffeine on post occlusive reactive hyperaemia before and after 7 days treatment with rosuvastatin.
We hypothesize that intracranial vessel wall atheromas are an important underlying cause of middle cerebral artery obstruction. To test our hypothesis we will perform high resolution intracranial vessel wall imaging with a 7.0 Tesla MRI scanner in…
Calculating the incidence of atherosclerosis in patients undergoing a CT-scan of the abdomen for other reasons. Calculating incidence of untreated risk factors for CVD in patients with atherosclerosis on the CT-scan.
This prospective randomised study has the primary objective to prove a reduction of postoperative wound infections after direct preoperative use of a microbial sealant in the form of Integuseal for vascular procedures on lower extremities. We aim at…
We aim to identify sequence variations within pedigrees and determine how these may result in CVD by studying the effect on cell phenotype.
a) To investigate the differences in adipokines and inflammatory markers between obese and normal weight children; b) to study these differences over age, and c) to correlate adipokine/inflammatory marker profiles to clinical parameters for obesity…
1. FDG PET scanning will permit evaluation of atherosclerotic disease in lower limbs (both density and activity of macrophages in local plaques) in patients with diabetes type 2 2. To obtain a more precise identification of ischemic borders…
To establish whether miRNA expression patterns in platelets, monocytes and plasma differ between subjects with premature CVD and a positive family history of premature CVD as compared to age en sex matched healthy controls.
In this trial we will investigate the following hypothesis:- Uremic vasculopathy develops, not only in large and medium sized conduit vessels, but also in the microcirculation.- There is a relationship between the rate of microcirculatory…
The primary objective is identification of a set of genes as candidate monocyte markers for acute coronary complications and subsequent identification of a prognosis classifier to discriminate vulnerable, stable, and control subjects, based on the…
1. to investigate whether the known chronic inflammatory and hyperoxidative state in patients with severely increased LDL is associated with dysfunctional HDL.2. to investigate whether CVD in FH is associated with dysfunctional HDL.
Main objective of this study is to develop an MRI protocol from which regional PWV can be assessed. An automated image analysis tool, indispensable for fast, reproducible and observer-independent data processing will be developed. The technique will…
Objectives of the study are to evaluate the clinical applicability of the PeriFlux System 5000 and to investigate the reproducability of its measurements on inter- (and intra-observer) variability.
To determine the inter- and intrarater reliability of 4 different methods to define stump volume in vivo, namely: water displacement method, Omega Tracer (Ohio Willow Wood), Design TT (Otto Bock) and circumference measurement (Sytzia-method).
To evaluate whether an increase in inflammatory- and coagulation parameters can be found in healthy volunteers with elevated hsCRP levels compared to age and BMI matched healthy volunteers with normal hsCRP levels