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Level of agreement in the assessment of carotid plaque composition between multi-contrast and multi-sequence MRI

Primary Objective:1. The primary objective is to investigate the level of agreement between scoring the presence of IPH on MR images acquired with MP-RAGE (conventional sequence) with scoring IPH on the multicontrast sequences. The level of…

Non-invasive MR imaging of vulnerable carotid artery plaque characteristics

The objective is to study reproducibility of the assessment of repetitive plaque deformation during the cardiac cycle in the carotid arteries by using advanced MRI techniques and state-of-the-art hardware.

In-vivo validation of non-invasive, magnetic resonance or computed tomography based patient-specific pressure model to determine the severity of common and external iliac artery obstructions, and the need for revascularization non-invasively.

The primary objective is validation of the MRA or CTA based personalized pre-procedural computer model, with intra-arterial pressure measurements at rest and during pharmacologically induced hyperemia, which serves as the gold standard.

Validation of Taxinomisis stratification tool through observational multicentre clinical trial

Aim of the trial is to validate the TAXINOMISIS system for risk stratification of carotid artery stenotic disease.

A Clinical PeRformancE EVAluatIon of a new Medtronic Coronary Drug-Coated BaLloon Catheter
for the treatment of De Novo Lesions, In-Stent Restenosis and Small Vessel Disease in Coronary
Arteries; The PREVAIL study.

To evaluate the clinical safety and efficacy of the Drug-Coated Balloon Catheter in the treatment of de novo lesions, small vessel disease or ISR with coronary lesions previously treated with drug-eluting or bare metal stents in native coronary…

Inorganic Pyrophosphate in Peripheral Arterial Disease

The objective of this study is to find out if low plasma PPi levels are involved in PAD. A second aim is find other serum calcification inhibitors involved in PAD.

A multicentre study to use non-invasive methods including hyperSPECTral imaging, thermal imaging and tcPO2 for monitoring tissue perfusion in vAsCULAR patients in-hospital and at home -- The SPECTACULAR-study

Our main objective is to determine normal ranges for oxyhemoglobin, deoxyhemoglobin, oxygen saturation, local skin temperature and tcPO2 during all phases (pre-/per-/post-intervention) of treatment of peripheral arterial disease. Secondary…

Trajectories of Frailty before and after Elective Vascular Surgery

Rationale:A study reporting the frailty trajectories after vascular surgery is currently lacking. The aim of this study is to evaluate the influence of the surgical intervention on the different domains of frailty, by measuring the characteristics…

DUAL pathway inhibition (low-dose rivaroxaban and aspirin) as compared to aspirin only to improve endothelial function in peripheral artery disease (PAD)

To study the effectiveness of low-dose rivaroxaban with aspirin in improving endothelial function in patients with symptomatic or stable PAD.

Consequences of (recurrent) hypoglycaemia on cardiovascular and inflammatory responses in patients with diabetes mellictus type 1, type 2 and healthy volunteers

Primary objective:* To investigate the consequences of (recurrent) hypoglycaemia on inflammatory responsesSecondary objectives:* To study the atherogenic consequences of (recurrent) hypoglycaemia* To study the molecular mechanisms involved in the…

The effect of clonal hematopoiesis on trained immunity; an exploratory study

To investigate the interrelatedness between clonal hematopoiesis of indeterminate potential (CHIP) and trained immunity.

Does Transient Cerebral Arteriopathy exist in adults? The course of unilateral intracranial large-artery arteriopathy.

Primary aim: to investigate the possible existence of *transient* or non-progressive non-atherosclerotic arteriopathy as a cause of AIS in young adults, and to describe the course of young adulthood unilateral intracranial arterial disease.Secondary…

Long Term Cardiovascular Disease Event Risk for Patients undergoing Non-Cardiac Surgery. A pilot study.

To determine changes (i.e. pre- vs. postoperative) in 10-year cardiovascular disease (CVD) event risk according to contemporary widely applicable risk models in patients with CVD risk factors who have undergone intermediate-to-high-risk non-cardiac…

Secondary Manifestations of ARTerial diseases in the Young with a chronic condition

The primary objective of this study is to establish the effect of cardiovascular risk factors on preclinical atherosclerosis in children with a chronic condition, and follow this up over time.

Limb salvage mechanisms after Superficial Vein Arterialisation in patients with severe chronic limb threatening ischemia

Objective: What pre and postoperative factors are associated with limb salvage in patients undergoing superficial venous arterialization (SVA)?Secondary objectives: • What is the vascular anatomy and blood flow in the associated veins in patients…

Advanced glycation end products in patients with peripheral artery disease or abdominal aortic aneurysms

The primary objective is to compare the amount, type and localisation of AGEs of the arterial wall of PAD, AAA and PAD+AAA in patients with and without diabetes mellitus.The secondary objectives are to explore the association between AGEs content of…

Detection of retinal and peripheral microvascular abnormalities in ankylosing spondylitis patients * a proof of concept study.

Primary objective: To investigate whether AS patients have increased signs of microvascular abnormalities of the retina, compared with healthy controls.Secondary objectives: to investigate:1. the peripheral microvascular function in AS patients,…

A PROspective, explorative cohort study to correlate CARdiac BIomarkers with late cardiac toxicity induced by radiotherapy alone or combined with anthracycline chemotherapy for hodgkin lymphoma (PROCARBI)

Hypothesis:We hypothesize that the combination of biomarkers (e.g. NT-proBNP, ST2, GDF15, Galectin 3, hsTn) is an early predictor of cardiac toxicity from radiotherapy and chemotherapy in a population at risk of developing late cardiac toxicity…

Improved drug eluting stent for percutaneous coronary intervention of the left main artery in a real world all-comers population

The primary objective is to establish the non-inferiority of the Synergy stent relative to the Xience stent for prevention of MACE. The effect measure is the difference in the rate of MACE in patients randomized to treatment with the Synergy ( index…

MR Intracranial Vessel wall Imaging in ischemic stroke patients and TIA patients

We hypothesize that intracranial vessel wall atheromas are an important underlying cause of obstruction of (one of the) artery(ies) of the anterior cerebral circulation. To test our hypothesis we will perform high resolution intracranial vessel wall…