469 results
The study investigates the inhibition of restenosis by the Paclitaxel-eluting PTA balloon Freeway versus stenting-PTA or PTA alone in the treatment of de-novo occluded, stenotic or reoccluded, restenotic superficial femoral (SFA) or popliteal…
The aim of the study is to measure whether there is a difference in LDL cholesterol levels or the 24 hour ambulatory blood pressure in individuals at high risk of cardiovascular disease when the polypill is taken in the morning compared with the…
The proposed project will have the following objectives:1. To investigate the correlation between 18F-FDG accumulation in plaques seen on PET-CT and plaque characteristics found with IVUS-VH and OCT.2. To investigate the correlation between…
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The primary purpose of this study is to determine the relation between a physically active lifestyle and the primary and secondary prevention of diseases and death.Using an online questionnaire, we will approach all civilian participants of the…
Assessment of triglyceride clearance in a FH population with variations in heparan sulfate biosynthesis.
Evaluate the effects of CER-001 - adminstered as iv infusion - on plaque size/burden in arteries, plaque inflammation in the artery wall and the rate of cholesterol transport in the body
The PRELHUDE study investigates the reversal of the ZAHARA3 study; whether subclinical congenital heart disease occurs in women who deliver prematurely for unknown reason. The biosamples taken during and after delivery will be used to determine…
The possibility to identify the risk of rupture of a carotid plaque will have tremendous impact in clinical decision making. Selection of candidates from surgery is based mainly on duplex ultrasonography, where now only the size of the stenosis is…
Primary: To evaluate the safety of the study device in patients presenting with severe aortic stenosis (AS) considered to be high risk for surgery.Secondary: To evaluate adverse events and study device performance.
The main objective of this pilot study is to evaluate the burden of an additional CTA and MRA procedure in patients, and to evaluate the quality of the CTA and MRA protocols.
To study the protective effect of pre-treatment with metformin on flow mediated dilation after 20 minutes ischemia and 20 minutes reperfusion. If metformin treatment indeed limits endothelial IR-injury, a second study will be performed in the same…
Primary: 1. To demonstrate migration of circulating white blood cells into atherosclerotic lesions in subjects with atherosclerotic disease via quantification with SPECT.Secondary: 2. To evaluate the relation between FDG-PET signal (reflection of…
Primary objective:- To obtain reference values for arterial stiffness, measured as PWV and AIx, and insulin resistance, calculated as HOMA-IR in normal weight, healthy adolescents in different Tanner stages.Secondary objectives: - To determine the…
A practical demonstration project in 5 European countries to show that intensive smoking intervention during a preventive cardiovascular risk management programme for patients with cardiovascular (CVD) or other atherosclerotic disease, asymptomatic…
Objective:The hypothesis of this study is that laboratory markers for blood coagulation, platelet activity and inflammation may help to identify patients at risk for a recurrent cardiovascular event after ACS. Secondary, we expect to find…
At CHDR, experience has been gained with the assessment of the in vitro inhibition by MAP kinases of the LPS-induced TNFα release in healthy male volunteers. However, relatively little is known on the inhibition by MAP-kinases in other populations.…
The objective of the study comprises the identification of (tissue) biomarkers related to the risk of re-amputaion, systemic atehrosclerotic manifestations and woundhealing in patients with critical limb ischemia by investigating tissue biopts at…
Primary Objective: a) Do EC/SMC from patients with cardiovascular disease and renal failure have inferior reproductive capacity compared to cells from control donors?Secondary Objectives: a) What is the interindividual variation of cultured…
The aims of the study are the following:1. to study the prevalence of coronary and aortic atherosclerosis assessed using 3 Tesla MRI 2. to study rate of change in coronary and aortic atherosclerosis measurements assessed using 3 Tesla MR imaging3.…