469 results
Evaluation of the rise in serum creatinine and the incidence of CIN following angiography in patients treated with a short hydration regime during 1 hour with sodium bicarbonate compared to a hydration regime with saline during 6-24 hours.
The primary objective of the study is to investigate the effect of interruption of anti-TNF-alpha therapy on endothelium dependent and independent vasodilation and the effect of intra-arterial infusion of infliximab on the endothelium dependent and…
The first (primary) objective (study 1) is to examine 1a) risk factors for volume loss in the entorhinal cortex and compare these with risk factors for volume loss in the rest of the hippocampus at 1.5T MRI over 7 years of follow-up; and to examine…
- To identify the causes of inflammation of adipose tissue, liver and blood leukocytes by focusing on the contribution of the gut microbiota taking into account dietary habits and genetic background.- To assess the influence of inflammation of…
To study the effect of 80 mg aspirin intake at bedtime compared with 80 mg aspirin intake on awakening on circadian rhythm of platelet function in healthy subjects.
The aim of the research is to demonstrate a possible significant difference in procedural success and / or clinical success of duplex-guided PTAs compared with conventional PTA in an RCT.The study describes the above hypothesis and has led to the…
Primary research question:To evaluate the impact of open versus endovascular invasive treatment in different types of surgery (AAA, CEA, LLR) on health status. Secondary research questions:To examine the prognostic impact of quality of life in PAD…
Primairy objective:- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks, measured by laser Doppler imaging, in SSc subjects with an early or active SSc pattern, measured with nailfold capillaroscopy (NFM), with…
To determine if Simvastatin can stimulate bone metabolism while simultaneously attenuate vascular calcification metabolism as quantified by Na18F PET CT imaging.
The aim of this study is to analyze and evaluate the feasibility and efficacy of treatment with a DEB of edge stenosis of covered stents in the SFA.
This pilot study examines the effects of supplementing the standard treatment interventions to improve mobility with modified supervised exercise therapy together with improvements in cardiovascular risk management by using an intensive risk factor…
Primary Objective: Improvement in myocardial blood flow and reverse remodelingSecondary Objective(s): Improvement in wall motion abnormalities, left ventricular function and NYHA class
Our main objective is to determine the effect of HO-1 induction by heme arginate infusion on insulin resistance and endothelial dysfunction related to MetS. Secondary objectives are to determine the effect on adipose tissue, adiponectin plasma level…
- To correlate clinical and biochemical cardiovascular risk factors to arterial wall 18-FDG uptake in large artery atherosclerotic lesions.- To correlate inflammatory markers to arterial wall 18-FDG uptake in large artery atherosclerotic lesions.
Primary Objective: comparing hemodynamic stability provided by titration of esmolol in addition to standard perioperative care including low-dose metoprolol to placebo and standard care.Secondary Objective(s): -comparing the incidence of…
Primary:to evaluate the effects of a moderate CYP3A4/5 inhibitor, diltiazem on the pharmacokinetics and pharmacodynamics (Thrombin and TRAP-induced platelet aggregation) of the study drug and its known metabolitessecundary:to evaluate the effects of…
We aim to study the short-term effects of postprandial hyperglycemia in patients with impaired fasting glucose and in patients with T2DM on aortic stiffness as measured by PWV. Secondly, we study the effects of postprandial hyperglycemia on the…
Our primary objective is to measurec glycocalyx volume with OPS imaging, before and after sublingual nitroglycerine-spray administration, in patients with premature atherosclerotic disease before the age of 40 years and a positiev family history for…
Primary: provide individual subjects with a cardiovascular risk profile and (when indicated) an advice to prevent cardiovascular disease. Secondary: collect data on the subject in a uniform and standardised manner that may help to to further…
The primary objective is to compare whether results from fusion imaging of MSCT-CA and myocardial perfusion SPECT lead to similar or different therapeutic choices as compared to results from myocardial perfusion SPECT and invasive coronary…