157 results
Primary Objective: To study long-term effects of premenopausal risk-reducing salpingo-oophorectomy (RRSO) on - cardiovascular status- bone mineral density- cognitionSecondary Objective: To study long-term effects of premenopausal RRSO on - quality…
Objective: The aim of the present study is to study the effect of increased adrenaline levels on the inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by administering exogenous adrenaline. Secondary aims consist of…
To investigate the effect of daily intake of 350 milligrams of magnesium citrate oral supplementation over a period of six months on calciprotein particle maturation time (T50) in serum, a measure of calcification propensity, and on vascular…
- to evaluate the prevalence of (sub)clinical CVD, cardiovascular risk factors and metabolic abnormalities among BC survivors treated with and without anthracyclines in two groups at (a) 5-7 years and (b) 10-12 years after diagnosis;- to…
This study aims to add the new ASL MRI sequence to the scanning protocol of the Centrum voor Ouderengeneeskunde Amsterdam (COGA) study (METC number 2017.148), to study the BBB integrity of the subjects included in the COGA study.
Primary Objectives• Employ a systems biology approach to identify a set of candidate biomarkers (BM) in circulation and/or pathways & mechanisms that correlate with particular non-AIDS defining comorbidities (ie NASH, CVD) in HIV+…
To collect data in order to create a registry that can be used for research in PXE, partly with an international questionnaire, and to measure PPi, ENPP1 activity, anti-retinal antibodies and cytokines, and retinal calcification in all patients…
The primary objective of this study is to establish the effect of cardiovascular risk factors on preclinical atherosclerosis in children with a chronic condition, and follow this up over time.
1.To determine whether there is additional value of performing CAC score, CTCA and total aorta calcification (TAC) burden as compared to traditional risk factors in the risk stratification in patients at high cardiovascular risk in predicting any…
The purpose of this study is to determine the patterns of vascular calcification in 5 different vascular beds in patients with CLI and a high ABI or incompressible vessels and compare these to the pattern found in CLI patients with a low ABI. As a…
The purpose of UCC-SMART is to create multidisciplinary care of patients with cardiovascular disease and to create at the same time, by building a vascular cohort, a scientific infrastructure. The main questions of UCC-SMART are:* What is the risk…
The main objective of the current study is to investigate platelet reactivity and underlying mechanisms using the novel multi-microspot analysis in a group of patients with SIHD and a healthy control group.
Objectives: 1. To what extent does the CVRM risk profile and co-morbid conditions differ between individuals with (UCC-SMART) and without (UHP-UCC) symptoms of heart failure, but with similar levels of echocardiographic structural- and functional…
Objective: Our main objective is to assess in detail risk factors for cardiovascular disease and cardiotoxicity and to compare heart function parameters, vascular parameters and biomarkers associated with cardiovascular function among 5- to 18-year…
Unravel the working of the immune system in South Asians, specifically the monocytes. We will also study whether the release of incretin hormones (GLP-1 and GIP) following a meal is lower in South Asians compared to Europids. The latter we will…
To examine the effect of adrenergic inhibition on the hypoglycaemia induced inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by performing a hyperinsulinaemic hypoglycaemic glucose clamp alongside infusion of α-ARA…
To describe the natural history of coronary artery disease in patients with diabetes mellitus type 2 through the use of serial CCTA, providing a comprehensive understanding of disease progression and its clinical implications over time.