35 results
The main objective is to show whether imaging characteristics assessed at baseline can predict clinical events in patients with a 30-69 % symptomatic carotid stenosis.
Primary Objective: Can catheter directed thrombolytic therapy, for the treatment of primary IFDVT, safely and effectively reduce post thrombotic morbidity after one year?Secondary Objective: Does catheter directed thrombolytic intervention have a…
The primary objective is to compare initial PTA with supervised exercise therapy for patients with disabling intermittent claudication due to an iliac artery lesion in terms of mobility, functional status, health related quality of life and cost-…
PrimaryTo investigate sensitivity and specificity of 3.0 Tesla MRI and MRS for dimension and composition assessment of carotid artery plaques, in particularly those plaques with lipid rich necrotic cores (LRNC), with the aim to develop these…
To determine the relationship between pericoronary adipose tissue (dys)function, in terms of the cytokine and adipokine secretion profile and histologic markers of inflammation, and coronary atherosclerosis.
The primary efficacy variable is the change in PV from baseline as assessed by 3 D ultrasonography after 78 weeks of double-blind treatment with OM 20-40 mg daily compared to ATE 50-100 mg daily.Secondary efficacy variables:Change from baseline PV…
The primary objective of the study is to demonstrate that among subjects undergoing primary PCI for anterior STEMI treated with a bivalirudin monotherapy anticoagulation strategy, the intracoronary infusion of an abciximab bolus with or without…
1) Determine differences in EPC and SMPC availability in the peripheral blood of T2DM patients with or without coronary artery disease (CAD) or peripheral artery disease (PAD) as well as in age- and sex-matched non-diabetic subjects with or without…
To investigate the frequency and the biology of the metabolic syndrome in childhood cancer survivors in order to find risk factors for cerebro- and cardiovascular diseases and to design preventive intervention strategies in indicated risk groups
To establish whether miRNA expression patterns in platelets, monocytes, plasma and endothelial cells differ between subjects with premature CVD and a positive family history of premature CVD as compared to age en sex matched healthy controls.
ObjectiveTo investigate the performance of paclitaxel-coated balloon expandable stainless steel coronary stent for the treatment of infrapopliteal stenoses and occlusions in patients with critical limb ischemia compared to percutaneous transluminal…
To assess the additional prognostic value of combined CTP and CTA parameters to baseline patient criteria and plain CT. Secondary objective is to subsequently use the best CTP and CTA indicators of outcome of infarct in a prediction model for…
To study the protective effect of pretreatment (both 3 day and 7 day) with rosuvastatin and atorvastatin on flow mediated dilation after 15 minutes ischemia and 15 minutes reperfusion.
The aim of the study is to demonstrate a basic mechanism that supports our hypothesis: Does increased respiratory function after administration of a bronchodilator in patients with COPD lead to elevated pulmonary retention of the harmful compounds…
Our primary objective is to measurec glycocalyx volume with OPS imaging, before and after sublingual nitroglycerine-spray administration, in patients with premature atherosclerotic disease before the age of 40 years and a positiev family history for…
Primary: provide individual subjects with a cardiovascular risk profile and (when indicated) an advice to prevent cardiovascular disease. Secondary: collect data on the subject in a uniform and standardised manner that may help to to further…
The primary objective is to compare whether results from fusion imaging of MSCT-CA and myocardial perfusion SPECT lead to similar or different therapeutic choices as compared to results from myocardial perfusion SPECT and invasive coronary…
In this investigation we want to regain more insight in the cardiovascular risk profile of RA patients. Also we want to find out which patients should have more attention concerning their cardiovascular risk profile and probably therapy for…
Primary Objective: In this study we investigate the adipose tissue depot-specific differences in adipocyte function and inflammation in patients with T2DM and subjects suffering from CVD compared to healthy subjects.Secondary Objective: Characterize…
Primary Objective: To determine whether a four week treatment with vildagliptin compared to acarbose improves endothelial dysfunction in patients with type 2 diabetes mellitus.Secondary Objective(s):-To determine the effect of vildagliptin on plasma…