17 results
Primary Objective: The Primary outcome is to evaluate the sensitivity of the ACCmax compared to the currently advised diagnostic method the ABI.Secondary ObjectivesTo evaluate the sensitivity, specificity, positive and negative likelihood ratios of…
Primary aim: To establish reference values for exercise-induced elevations of cTn concentrations following walking, cycling and running exercise. Secondary aim: Assess the prevalence of (sub)clinical coronary artery disease in individuals with high…
This proof-of-concept study aims to prove the safety and usability of OCT in BTK lesions. Furthermore, it aims to provide information on the discrepancy between objective measurement of the vessel diameter using OCT versus the estimated vessel…
Primary objective: in this study, we want to investigate the performance of FH identification with a new approach using existing clinical laboratory data in which patients with severe hypercholesterolemia (LDL-C > 99.5th percentile for age…
Primary Objective:• To evaluate the effect of an online 12 week plant-based dietary program compared to usual diet on change in glycated hemoglobin and estimated relative CVD risk in persons with type 2 diabetes. Secondary Objective(s): • To…
To investigate the effects of ICIs (anti-CTLA4, anti-PD1, combination anti-CTLA4/PD1) on vascular inflammation (PET-CT) in stage III melanoma patients. We hypothesize that the increase in vascular inflammation will be greater in the exposure group…
To assess whether and to what extent dual therapy clopidogrel 75 mg/acetylsalicylic acid 80 mg daily is superior to monotherapy clopidogrel 75 mg daily, in reducing the combined endpoint all-cause death and cardiovascular adverse events after one-…
To investigate the role of the immune system in the etiology and prognosis in an acute ischemic stroke (or TIA) in young stroke patients.
The main objective of the current study is to determine the feasibility of spatial and temporal quantification of swirling blood flow inside the SFA of patients treated with the BioMimics 3D stent, using high framerate (HFR) contrast enhanced…
To study the impact of AKCEA-APOCIII-LRx on lipid and inflammatory measurements in the fasting and postprandial phase.
This study has been transitioned to CTIS with ID 2023-507795-51-00 check the CTIS register for the current data. The primary objective of this study is to evaluate the effect of obicetrapib on the risk of major adverse CV events (MACE), including CV…
Synopsis, page 4-5OBJECTIVES:The primary objective of this study is to evaluate the effect of obicetrapib on LDL-C levels at Day 84.The secondary objectives of this study include the following:• To evaluate the effect of obicetrapib on LDL-C levels…
Primary objective:To evaluate the performance of bST and echoPIV in quantifying spatiotemporal blood flow velocity profiles in the CA and SFA of healthy volunteers in comparison to 4D flow MRI.Secondary objective:- To determine the correlation of…
To investigate the feasibility of skin perfusion measurements of lower limb tissue in 20 PAOD patients with continuous ICG-VA. Feasibility is defined as the ability to detect hypo perfusion in the diseased leg in comparison with the patient's…
Our main aim for the future is to improve diagnostic testing for FLIA. NIRS and pedal force measurements are very promising in this respect, since they may be used in a clinical setting, in a research laboratory, and in the field in a high-…
This study has been transitioned to CTIS with ID 2024-513486-39-00 check the CTIS register for the current data. The main objective of this study is to determine the effect of colchicine on the progression of moderate AS in asymptomatic patients.
To demonstrate superior efficacy and non-inferior safety of the SELUTION SLR 014 DEB compared to PTA (uncoated balloon) in the treatment of peripheral arterial disease (PAD) in the BTK arteries in CLTI patients.