26 results
The objective of this clinical study is to assess the safety and effectiveness of the Apollo Intravascular Lithotripsy (IVL) System for lithotripsy-enhanced balloon dilatation of calcified, stenotic de novo coronary lesions prior to stenting.The…
The objective of this clinical study is to assess the safety and effectiveness of the Bolt IVL System for the lithotripsy-enhanced percutaneous coronary intervention of de novo, calcified, stenotic coronary lesions prior to stenting. The data is…
Unravel the working of the immune system in South Asians, specifically the monocytes. We will also study whether the release of incretin hormones (GLP-1 and GIP) following a meal is lower in South Asians compared to Europids. The latter we will…
AGELESS has 3 specific aims - they all refer to patients with carotid atherosclerosis:1. To compare patients with and without carotid intraplaque hemorrhage, as assessed with MR-Plaque Imaging, in terms of apoB, Lp(a) levels and traditional…
The primary objective of this trial is to assess the efficacy of immediate CAS among patients with acute ischemic stroke treated with EVT and a severe ipsilateral proximal carotid artery stenosis (>50%) or occlusion and compare this with the…
The primary objective of this trial is to demonstrate the superiority of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis for primary patency when compared to bare metal stenting for the treatment of patients with complex iliac occlusive…
Primary Objective:Our primary goal is to investigate the feasibility of a large pragmatic study of the effectiveness of a tailored MLI for patients with depression in general practice and to evaluate potential barriers and facilitators in a process…
This proof-of-concept study aims to prove the safety and feasibility of FFR in BTK lesions. Safety is defined here as conducting the FFR measurement without complications caused by the FFR measurement. Feasibility is defined here as successfully…
The objective of the HORIZON trial is to demonstrate and provide long-term clinical data on safety and performance of the Qmedics EXIST NiTi Stent System type FLEX & PULL for treating de novo or re-stenotic symptomatic atherosclerotic…
The aim of this study is to assess the clinical value of bedside tests compared to DUS to detect PAD in patients with diabetes-related foot ulceration, with special emphasis on the ACCmax.
To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.
Objective: The aim of the present study is to study the effect of increased adrenaline levels on the inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by administering exogenous adrenaline. Secondary aims consist of…
Assess the predictive capabilities of LSCI on the effect of endovascular revascularization on the microcirculation of the feet over time and what could this mean for clinical decision-making.
The primary objective of this study is to determine the nutritional intake, nutritional status, and physical activity level at various moments post-lower limb amputation (i.e., during hospital admission for amputation, at 5 weeks post-amputation, at…
The primary aim of this study is to correlate regional muscle perfusion measured with [15O] H2O PET in patients with advanced PAD to local skin perfusion measured with TcPO2. Secondary objectives are to compare pre-revascularization perfusion rates…
This study aims to add the new ASL MRI sequence to the scanning protocol of the Centrum voor Ouderengeneeskunde Amsterdam (COGA) study (METC number 2017.148), to study the BBB integrity of the subjects included in the COGA study.
The primary study objective is to identify the effects of percutaneous interventions for branch PA stenosis on exercise capacity in patients with d-TGA, ToF and TA. The secondary objectives are 1) to assess the effects of percutaneous interventions…
This proof of principle study aims to provide the safety and feasibility of OCT in patients with primary shunt failure requiring re-intervention. Safety is defined as conducting the OCT measurement without complications caused by the OCT measurement…
The primary objective is to compare a composite endpoint of major CV events and all-cause death between control and intervention group.Secondary objectives are the comparison of patient-centered outcomes between the two groups.
Primary Objective: 1. To determine the feasibility and clinical relevance of quantifiable parameters from intraoperative ALFA-measurements. Secondary Objective(s): 1. Determine the intraoperative applicability of ALFA. 2. Determine the effect of…