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Safety and efficiency of home treatment based on Hestia rule versus Hestia rule and NT-proBNP in patients with acute pulmonary embolism

Optimization of safety of risk stratification for outpatient treatment in pulmonary embolism, through randomization between Hestia approach with or without NT-proBNP measurement.

Prospective registry of management and outcome of bleeding complications in patients treated with non-vitamin K antagonist oral anticoagulants (NOACs)

Primary objectiveTo assess the outcome of NOAC associated bleeds and emergency invasive surgery or procedures. Secondary objectives1) To describe the treatment of patients presenting with NOAC associated bleeding2) To evaluate the current…

Expedite and facilitate diagnostic work up of transient ischemic attack and minor ischemic stroke: dynamic 320-detector row CT angiography of cardiac and carotid sources of emboli compared to currrently used diagnostic procedures

Main study objective of this study is:To evaluate whether the 320-detector volumetric CT technology can replace carotid duplex scanning and TEE in the diagnostic workup in TIA/IS patients. Specific aims of this main study objective are:1. To assess…

A prospective Randomised, open label, blinded endpoint (PROBE) study to Evaluate DUAL antithrombotic therapy with dabigatran etexilate (110mg and 150mg b.i.d.) plus clopidogrel or ticagrelor vs. triple therapy strategy with warfarin (INR 2.0 - 3.0) plus clopidogrel or ticagrelor and aspirin in patients with non valvular atrial fibrillation (NVAF) that have undergone a percutaneous coronary intervention (PCI) with stenting

See section 2.2 of the protocol.The main objective of this study is to compare a DAT regimen of 110mg dabigatran etexilate b.i.d. plus clopidogrel or ticagrelor (110mg DE-DAT) and 150mg dabigatran etexilate b.i.d. plus clopidogrel or ticagrelor (…

The Need for Titration or Monitoring of Direct Oral Anticoagulant Treatment: The MONDOAC and KIDOAC study

To determine the within and between variability of pharmacokinetic (PK) profiles in patients treated with DOACs in daily practice

Dutch randomized trial comparing Ultrasound-accElerated Thrombolysis with standard dose Urokinase versus half dose Urokinase for thrombo-embolic infra-inguinal arterial disease (DUET II)

To demonstrate that the use of US-accelerated catheter-derived thrombolysis in patients with recently (less than 7 weeks) thrombosed infra-inguinal bypass grafts or native arteries with half the dose urokinase (50.000 IU/h) will significantly reduce…

Anti-Xa activity after a reduced therapeutic dose of nadroparin in patients with renal impairment using a dosage guideline of the Dutch Federation of Nephrology

The primary objective of this study is to determine the anti-Xa activity after a reduced therapeutic dose of nadroparin in patients with an eGFR < 60 ml/min in comparison with the anti-Xa activity after a standard therapeutic dose of…

Exogenous creatine kinase and platelet aggregation

In this study, we will assess the reproducibility of the observed dose-dependent inhibiting effect of CK on platelet aggregation.

Long-term treatment for cancer patients with deep vein thrombosis or pulmonary embolism - a randomized open label study

The primary efficacy objective is to evaluate whether LMWH is superior to VKAs in the long-term treatment of symptomatic VTE in cancer patients who completed 6 to 12 months of anticoagulant treatment. Two aspects are important: the efficacy with…

Rosuvastatin use to improve the coagulation profile in patients with venous thrombosis: The STAtins Reduce Thrombophilia (START) Study

To understand why statins are able to decrease the risk of developing venous thrombosis, by analyzing whether statins can influence pathways that inhibit coagulation.

Vitamin K1 to slow vascular calcification in hemodialysis patients (VitaVasK)

The aim of the study is to show that a therapy based on a thrice weekly administration (i.e. at each HD session) of vitamin K1 for a period of 18 months attenuates the progression of coronary artery and thoracic aortic calcifications compared to…

Tourniquet study: Is the high thrombosis risk after knee arthroscopy caused by limb-tourniquet application? A randomized clinical trial into the effect of tourniquet use on the coagulation system.

To investigate the effect of tourniquet application on the coagulation system in patients undergoing a knee arthroscopy. A finding of more prominent activation of the coagulation system with tourniquet use than with non-use will create an important…

Haemostatic derangements after acute severe colitis and implications for duration of thromboprophylaxis.

This study aims to provide a comprehensive assessment of global coagulation parameters in patients with ASC both in hospital and up to 12 weeks after discharge. The results will help define the period at risk for VTE and inform the rationale for…

Role of periodontitis in accelerated ageing in HIV-infected patients

1. Determine the relationship between periodontitis and HIV-related immune activation and hypercoagulability.2. Explore the role of oral microbiota as effect modificator of the relationship between periodontitis and immune activation in HIV-infected…

Multi Center Clinical trial of endovascular treatment of acute ischemic stroke in the Netherlands.

The primary objective of this study is to estimate the effect of endovascular treatment on overall functional outcome after acute ischemic stroke of less than six hour duration, in patients with a symptomatic anterior circulation IAO. The secondary…

A randomized, double-blind, placebo-controlled, 4-period, two part cross-over study to evaluate the potential interaction effect between 4 mg/kg and 16 mg/kg sugammadex and enoxaparin or unfractionated heparin on anticoagulation activity in young healthy male volunteers

To investigate the potential of an interaction between 4 mg/kg and 16 mg/kg sugammadex and enoxaparin or UFH on anticoagulant activity in young healthy male volunteers.

Multiple-Dose Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and
Tolerability of Apixaban in Paediatric Subjects with an Indwelling Central Venous
Catheter

There is no formal primary research hypothesis to be statistically tested. The purpose of this study is to evaluate the pharmacokinetics, the pharmacodynamics, the safety profile and tolerability following multiple oral doses of apixaban in…

INTERVENTIONAL MANAGEMENT OF STROKE TRIAL CLINICAL PROTOCOL - IMS III
A phase III, randomized, multi-center, open label, 900 subject clinical trial that will examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV rt-PA (Activase®/Actilyse®) alone when initiated within three hours of acute ischemic stroke onset.

The primary objective of the trial is to determine if ischemic stroke subjects with a baseline NIH Stroke Scale Score (NIHSSS] >= 10 (8-9 with positive CTA) treated with recombinant tissue plasminogen activator (rt-PA; [Alteplase recombinant…

HDL profiling in patients with deep vein thrombosis

Does a deep vein thrombosis coincide with changes in HDL protein composition? What are the effects of anticoagulant therapy on HDL protein composition during therapy and after discontinuation of therapy?

Athero-thrombosis risk in patients with venous thrombo-embolism

Primary objective:To determine the individual cardiovascular risk profile, using validated risk score screening methodologies (Framingham, PROCAM, Reynolds Risk Score and SCORE) in patients with VTE to evaluate how many patients are at risk for…