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Vitamin c to Improve Tissue healing by Administration of Multiple INtravenous dosages

PrimaryImproved woundhealing in 30 days in patients with an open revascularisation of the lower extremities after treatment with 4 dosages of 2 grams ascorbic acid on 4 consecutive days. (First dosage 1 hour preoperative)SecondaryWith preoperative…

Prevent CardioKids

The aim of Prevent CardioKids is to evaluate to what extend disturbed vascular function markers are present in children of different weight categories and whether these are age dependent. Also differences * and relationships between * vascular…

Double-blinded, randomised, placebo-controlled, multicentre , Phase IIa study to investigate the effect, safety and tolerability of phosphorylcholine human monoclonal antibody (PC-mAb) 3G10 on arterial inflammation, together with safety and tolerability, in subjects with elevated lipoprotein a (Lp[a ])

1. The primary objective is to assess the effects of four 250 mg PC-mAB (also referred to as "3G10") once monthly intravenous injections on monocyte function ex vivo. The secondary objectives are to:1. assess the functional effects of 3G10…

Concomitant presence of celiac disease in patients with type 1 diabetes mellitus; investigation of the microvascular function

Aim of the study is to determine the microvascular function in type 1 diabetes patients with concomitant celiac disease

Are AGEs, as a predictor of increased risk for cardiometabolic syndrome, increased in shift workers?

The aim of this study is to investigate skin AGEs, as a predictor of increased risk for cardiometabolic syndrome, in a shift work population as compared to non-shift workers to assess its potential as an early assessment of the actual risk for…

The effect of cervical spinal cord stimulation on the cerebral blood flow

Effect of SCS on CBF

The effect of hesperidin administration on endothelial function and gut barrier function

To determine the chronic and acute effects of daily administration of hesperidin on cardiovascular and intestinal health as assessed by investigation of endothelial function, blood pressure, heart rate, glucose/insulin metabolism, lipid metabolism…

The effects of oligomeric procyanidins (OPCs) on vascular function, biomarkers of oxidative stress and inflammation in smokers: a pilot study

To evaluate the potential attenuating effects of an eight-week supplementation with 200 mg OPCs per day on macro- and microvascular function as well as on systemic biomarkers of inflammation and oxidative stress in healthy smoking subjects.

SPRING-study: Efficacy of paramedical use of software-guided cardiovascular prevention programs in a first-line general practitioner setting, comparison of care provided via telemonitoring or within general practice setting.

Which is the best way for cardiovascular prevention according to the Dutch general practitioner's guidelines, in a general pratitioner's office?a. By a nurse practioner, supervised by the general practitioner, while the frequency and…

Cardiovascular and metabolic health after the challenge of pregnancy: development and evaluation of a strategy of individual health risk appraisal and tailored intervention

1. To develop a postpartum strategy of appraisel of cardiovascular and metabolic health after pregnancies, complicated by PE, IUGR or GD.2. To develop and evaluate the feasibility of a lifestyle intervention strategy.3. To design a study proposal…

Curcumin study: Plasma concentrations of curcumin, piperin and genistein in subjects using over the counter supplements

The aim of this study is to investigate if curcumin is detectable when subjects use curcumin supplements in daily life.

A randomized controlled trial comparing venous stenting with conservative treatment in patients with Deep Venous Obstruction

Primary Objective: Measure QoL (VEINES QoL/Sym) change in patients with DVO at one year after PTA and stenting compared to conventional therapy (short class II elastic compressions stockings, exercise, lymph drainage therapy and the use of (pain)…

A Long-Term Outcomes Study to Assess STatin Residual Risk Reduction with EpaNova in HiGh Cardiovascular Risk PatienTs with Hypertriglyceridemia (STRENGTH)

Primary ObjectiveThe primary objective is to evaluate the effectiveness of adding Epanova to statin therapy (with or without ezetimibe) for lowering MACE (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, emergent/elective…

A long term, randomised, double blind, placebo-controlled study to determine the effect of albiglutide, when added to standard blood glucose lowering therapies, on major cardiovascular events in patients with Type 2 diabetes mellitus (Harmony Outcomes Trial, GLP116174)

Primary: Time to first occurrence of MACE (cardiovascular death, myocardial infarction, or stroke) [Non-inferiority].Secondary: Time to first occurrence of MACE [Superiority], MACE or urgent revascularization for unstable angina, individual…

selective prevention of cardiovascular disease witH panElmAnagement and integrated LifeSTYlE inTervention in primARy care (HEALThY HEARt)

The primary goals of this project are to 1) evaluate the effectiveness, 2) identify effective elements and 3) find successful implementation factors of an integrated group-based lifestyle intervention programme in primary care.

A Qualitative Phase 1 Study to Development a New Patient-Reported Outcome Instrument for Acute and Chonic Wounds: The WOUND-Q

The aim of our study is to develop a new PRO instrument for acute and chronic wounds. Our 3-phased approach involves a qualitative study, an international field-test and a psychometric study. Patients, healthcare providers and other stakeholders…

Moderate Alcohol and Cardiovascular Health Trial

The primary objective of the MACH15 Trial is to determine the effects of one US serving of alcohol (~15 g) daily compared to no alcohol intake on the risk of incident cardiovascular disease among adults at above-average cardiovascular risk over an…