27 results
A prospective randomized phase III clinical trial to study the effectiveness of pathogen-reduced platelet concentrates in plasma, stored for up to 7 days, and compare these with untrested platelet concentrates in plasma, stored for up to 7 days. The…
The objective of the study is to examine the relation between changes in cortical activity during movement observation and execution, and changes in motor function and motor control after stroke. The hypotheses to study this objective are: 1. Brain…
Primary Objective:- To evaluate the efficacy of PF-04360365 (ponezumab) in subjects with probableCAA as compared to placebo on a BOLD fMRI measure of cerebrovascularreactivity.Secondary Objectives:- To evaluate the efficacy of PF-04360365 (ponezumab…
Cost effectiveness of augmented cognitive behavioural therapy for post stroke depression and anxiety
Our main objective is to investigate whether an augmented CBT leads to the reduction of depression and anxiety symptoms in stroke patients. We will compare the outcomes of this experimental treatment with a control intervention (i.e., computerized…
Determine the potential impact of a set of cognitive games in people with cognitive difficulties after stroke.
To assess the normalization (reversal) of coagulation assays upon administration of two dosages of Prothrombin Complex Concentratre (PCC, Cofact®) in healthy volunteers treated with either rivaroxaban or apixaban
The primary aim of this study is to evaluate the effects of a structured, progressive task-oriented fitness training program applied in a group of 8 to 10 patients on perceived outcome of mobility after stroke when compared to individually-tailored…
The primary objective of the study is to evaluate the efficacy of aliskiren, valsartan and a combination of both drugs versus placebo in lowering levels of NT-proBNP in stabilized patients post ACS
The objective of our study is to investigate whether platelet transfusion within 6 hours after onset of ICH can improve functional outcome by limiting haematoma growth in patients using PAI.
The objective of the current study is to determine whether cognitive, emotional, behavioural, and personality explain individual difference in fatigue symptomatology. Furthermore, this study wants to examine whether fatigue is a risk marker for…
The objective of the present study is to investigate the course of psychosocial functioning in stroke patients and their partners, during the first 2 years post-stroke, to investigate factors predicting psychosocial functioning in stroke patients…
To compare the (cost-)effectiveness of early surgical hematoma evacuation versus a conservative treatment in elderly patients with a traumatic ASDH.
This study has been transitioned to CTIS with ID 2024-514927-40-02 check the CTIS register for the current data. To evaluate the efficacy of TXA to prevent surgery for cSDH
This study has been transitioned to CTIS with ID 2024-511679-14-00 check the CTIS register for the current data. Our primary objective is to evaluate whether aSAH patients treated with therapeutic dose nadroparine have a lower 30-days mortality rate…
In oral FXa inhibitor-treated patients with acute intracerebral bleeding, the objectives of this study are as follows:Primary Efficacy Objective:To evaluate the effect of andexanet versus usual care on the rate of effective hemostasis.Secondary…
The effects of DPA compared to STOPP-START approach (SSA) prescribing on adverse drug reactions, medical complications, hospital readmission, quality of life in hospitalized geriatric patients with sarcopenia
Primary aim: Examine whether and to what extent fatigue and quality of life of patients with SAH improve after participating in RE-SAB.Secundary aims: (1) Examine whether and to what extent physical activity level, physical fitness, coping style,…
The primary objective of this randomized controlled trial is to determine whether decompressive surgery and best medical treatment in patients with spontaneous ICH will improve outcome compared to best medical treatment only. Secondary objectives…
In oral FXa inhibitor-treated patients with acute intracranial bleeding, the objectives of this study are as follows:Primary Efficacy Objective:• To evaluate the effect of andexanet versus usual care on the rate of effective hemostasis.Secondary…
Study hypothesisThe primary study hypothesis states that oral treatment with tacrolimus will reduce the bleeding severity in HHT.Research question and primary outcomeWhat is the effect of oral tacrolimus treatment on hemoglobin levels in HHT…