181 results
Phase 1:- The main objective of this phase of the study is to determine the variation of UAC over 8 weeks time in toddlers. - The secondary objective of this phase is to determine the variation of UAC over 3 days time.Phase 2:- The main objective of…
The objective of this study is to evaluate safety and blood pressure response after renal denervation in patients with uncontrolled hypertension on three standard antihypertensive medications compared to a sham-controlled population. These data, in…
The primary aim for this study therefore is:1. To study the effects of an 8-week exercise training on RNA expression profiles in adipose tissue and skeletal muscle in obese individualsSecondarily we also aim:2. To relate changes in RNA expression…
Main objectives are twofold: 1) To investigate the feasibility of RNS in patients with therapy resistant hypertension, which is assessing the functional distribution of renal nerves using 3D imaging and differential pacing modalities.2) To…
To establish the role of renal sympathetic modulation on renal blood flow, metabolism and oxygenation we propose three closely related series of experiments.Group 1: Sympathoactivation in healthy humans 12 healthy volunteers will undergo a graded…
Compare the hemodynamic response to pelvic and conventional LBNP and assess head motion.
The objective of this study is to evaluate safety and blood pressure response after renal denervation in patients with uncontrolled hypertension compared to a sham-controlled population, in the absence of antihypertensive medications. These data,…
The main goal is to assess differences in the maximal BP response compared to baseline using beat-to-beat registration of BP between subjects with and without established differences between home and ambulatory BP of at least 10/5 mmHg. As a…
Primary Objectives: 1. To assess the prevalence of AAV related damage in AAV, i.e. cardiovascular damage and impaired QOL.Secondary objectives2. To assess whether there exists an association between cardiovascular disease, QOL and disease activity…
The primary endpoint will be descriptive histology on placental bed biopsies and placenta in healthy pregnant women or women with preeclampsia and/or IUGR in need of caesarean section. In particular, the study will aim to find the degree of…
Objective: To test the efficacy and safety of percutaneous renal sympathetic denervation of the native kidneys in the treatment of uncontrolled hypertension in kidney transplant recipients.
To validate and compare smartphone-connected blood pressure monitors produced by Withings, Qardio and iHealth with the gold standard and a validated automatic blood pressure monitor.
To provide UT-15C for eligible subjects who participated in study protocol TDE-PH-310
The primary objective is to determine if there is a difference in autonomic function between patients with Alzheimer*s disease (MCI and AD) and a matched control group. The secondary objectives will be explorative and aimed to investigate…
To study the clinical value of pressure and flow assessment for predicting treatment response to PTRA and validate the pressure gradient assessment by CFD in patients with available CT angiography.
The primary objective is to assess the hypoxic challenge test, combined with echocardiography, as a function test for the pulmonary and pulmonary vascular system in preterm born children with and without bronchopulmonary dysplasia. Secondary…
To assess the long-term BP lowering effect of renal denervation using a dedicated circumferential ultrasound balloon catheter in patients with resistant hypertension.
The objective of this study is to relate different vascular phenotypes, based on macro- and microvascular measurements, to changes in cognitive and physical functioning in a geriatric population.
Primary Objective: 1. to determine unique inflammatory VOC profiles that distinguish patients with PAH-CTD, CTEPH and IPAH from SSc and SLE (CTD) patients without PAH. Secondary objectives:1. to test whether these unique inflammatory VOCs associates…
In this study we want to investigate if there is a difference in exposure to losartan and perindopril between younger and elderly patients. Furthermore, the results will enable us to correlate detailed PK data with PD data, which can lead to a more…