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Aldosterone-Renin Ratio to diagnose Primary Aldosteronism and a Tool to select Proper Antihypertensive Treatment. The Dutch ARRAT Study.

With a standardized approach in a population with difficult to treat hypertension we want to explore how frequenty PHA is a cause of hypertension and what the test characteristics of the aldosterone-renin ratio are. Additionally we want to…

Insulin-induced microvascular activity in patients with essential hypertension: possible interactions with angiotensin II - Amendement 24-09-2007

The goal of this study is examining the acute effects of insulin on microcirculation in hypertensive insulinresistant subjects and investigate if angiotensine II influences these effects. Amendement: The goal of the amendement is to exame the…

IJsselstein Screening for Central Obesity to detect metabolic syndrome

1) To determine the prevalence of MetS in the patient population of the MMIJ in IJsselstein aged 20 to 70 years2) To assess the effectiveness of population screening for MetS by general practitioners in a medium-size city in the Netherlands

An eight-week, randomized, double-blind, parallel-group, multicenter study to evaluate the efficacy and safety of the combination of aliskiren/HCTZ (150/25 mg and 300/25 mg) in comparison with HCTZ 25 mg in patients with essential hypertension not adequately responsive to HCTZ 25 mg monotherapy

The primary objective of this study is to demonstrate the efficacy of the combination therapy of aliskiren (150 mg and 300 mg) and HCTZ 25 mg in hypertensive patients who do not show sufficient blood pressure response to a 4-week treatment of HCTZ…

Excercise induced circulatory improvement in formerly preeclamptic women

To test the hypothesis that in formerly preeclamptic women with a low plasma volume a month physical excercise improves vascular and hemodynamic functions.

Validation of the measurement of venous compliance during orthostatic stress

To determine the best method of measuring venous compliance in women.To determine the influence of orthostatic stress on venous compliance and the best method to measure VC during orthostatic stress.

A 54-week, open-label, multicenter study to assess the long-term safety and tolerability of the combination of aliskiren 300 mg / valsartan 320 mg in patients with essential hypertension.

The Primary objective is to assess the long-term (6 month and 12 month) safety of the combination of aliskiren 300 mg/ valsartan 320 mg in patients with essential hypertension (msDBP > 90 mmHg and < 110 mmHg.