69 results
1. to investigate early haemodynamic alterations and endothelial function in young prehypertensive medical students; 2. to examine the possbility to improve these haemodynamic changes after exposure to an endothelial dependent (salbutamol) and…
To determine the cardiovascular changes in response to orthostatic stress in women with a vascular complicated obstetric history or recurrent miscarriage.
To determine the best method of measuring venous compliance in women.To determine the influence of orthostatic stress on venous compliance and the best method to measure VC during orthostatic stress.
Phase 1:- The main objective of this phase of the study is to determine the variation of UAC over 8 weeks time in toddlers. - The secondary objective of this phase is to determine the variation of UAC over 3 days time.Phase 2:- The main objective of…
To establish the role of renal sympathetic modulation on renal blood flow, metabolism and oxygenation we propose three closely related series of experiments.Group 1: Sympathoactivation in healthy humans 12 healthy volunteers will undergo a graded…
The main goal is to assess differences in the maximal BP response compared to baseline using beat-to-beat registration of BP between subjects with and without established differences between home and ambulatory BP of at least 10/5 mmHg. As a…
The primary endpoint will be descriptive histology on placental bed biopsies and placenta in healthy pregnant women or women with preeclampsia and/or IUGR in need of caesarean section. In particular, the study will aim to find the degree of…
The objective of this study is to relate different vascular phenotypes, based on macro- and microvascular measurements, to changes in cognitive and physical functioning in a geriatric population.
Primary Objective: 1. to determine unique inflammatory VOC profiles that distinguish patients with PAH-CTD, CTEPH and IPAH from SSc and SLE (CTD) patients without PAH. Secondary objectives:1. to test whether these unique inflammatory VOCs associates…
Research question: Is maternal microbiome dysbiosis in MOB an underlying mechanism in the pathophysiology of adverse maternal pregnancy and offspring outcome?Objectives: Analyse the differences between the gut and vaginal microbiome, maternal and…
Part I- To determine the impact of PE on incidence of macro-and micro-vascular dysfunction reflected by surrogate measures for coronary artery disease (CAD) and HFpEF, and potential deterioration over time.- To perform a genome wide association…
The precise pathophysiology for hypertension causing brain damage is still unclear, although microvascular dysfunction is thought to play an important role. Therefore, in this study the small cerebral vessels will be studied in more detail. The main…
The main objective of this study is to obtain valuable biomarkers that are useful in the prediction of the presence of (subtypes of PH) and/or treatment responses. Nucleic acid expression patterns will be determined in plasma and peripheral blood.…
To identify novel (causal) risk factors, including biomarkers and genetic determinants for disease progression and (severe) diabetes complications in people with T2D, in order to develop new, more targeted and effective therapies that will improve…
Primary objectives:1. Examine abnormalities in brain (micro)structure and vascular function in patients with hypertension aged 18-40 2. Determine the effects of blood pressure increase and subsequent blood pressure reduction during a period of…
The primary objective of this study is to investigate how the vascular regulation is altered in the maternal as well as placental vasculature of women with pregnancy disorders (preeclampsia, pregnancy-induced hypertension, FGR, preterm birth,…
Primary objective:To test the hypothesis that the calcium channel blocker amlodipine has a superior beneficial effect on cerebrovascular reactivity in patients with symptomatic SVDs when compared to either the Angiotensin II type 1 (AT1) receptor…
To investigate the role of the immune and coagulation system on the progression of cerebral SVD
In this study we aim to elucidate effects of dietary sodium intake on:1. Body weight and blood pressure2. Microcirculation by studying the capillary network during high and low sodium conditions.3. Adaptive and innate immune system by studying…
The primary objective of this study is to assess the effect of oral butyrate on blood pressure. Secondary objectives are to assess the effect of oral butyrate on faecal and plasma SCFA levels, gut microbiome composition, diuresis, renin and…