69 results
Primary objective:To determine BBB integrity and the interplay with microvessel function including PVS and CVR response to CO2 breathing challenge in sporadic and monogenic presentations of human SVDs.Secondary objective:To determine the…
The objective of this study is to compare OCT-A findings between five groups of non-glaucomatous subjects characterised respectively by a) low symptomatic, b) low asymptomatic, c) normal asymptomatic, d) untreated high asymptomatic, and e) treated…
Test the effect of five different sodium- and potassium salts in patients with chronic kidney disease.
To prospectively study the effect of salt restriction on the rise in blood pressure in response to anti-cancer treatment with the VEGF inhibitor sunitinib and regorafenib.
Primary objectives:1. Is plasma aldosterone concentration associated with microvascular function, specifically insulin-mediated capillary recruitment, in obese subjects?2. Does mineralocorticoid receptor antagonism result in improvement of…
We hypothezise that hypertension in pregnancy, spontaneous preterm birth and cardiovascular disease in later life share pathophysiological features of endothelial dysfunction. We will investigate this on two levels including local on tissue level…
Objectives: The main objective is to study renal tissue in relation to renal function before and after nephrectomy with a specific focus on microvascular structure and function. A second objective is to study renal microvascular alterations in…
In this study we will identify the role of the endothelial GAGs in Na+ and volume homeostasis. Is there a link between the ESL and individual susceptibility to Na+-excess?
We aim to identify if pediatric PAH patients have increased plasma IL-1β and IL-18 compared to control participants, as well as increased caspase-1 cleavage and NLRP3, IL-1β and IL-18 mRNA expression in PBMCs, reflective of inflammasome activation.…