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IMPella versus IABP REduces mortality in STEMI patients treated with primary PCI IN SEVERE and deep cardiogenic SHOCK.
An international multicenter, randomized trial of the Impella cVAD (left ventricular assist) device versus Intra Aortic Balloon Counter Pulsation (IABP) therapy for acute ST-elevation myocardial infarction patients treated with primary PCI in severe and deep cardiogenic shock

The primary objective of this study is to determine whether the Impella cVAD device vs. IABP therapy leads to a higher 30 day survival rate in shock STEMI patients in the setting of primary PCI.

Study on the effects of hyperoxemia on hemodynamic parameters and cardiac function

To study dose-dependent hemodynamic and microcirculatory changes during oxygen supply in mechanically ventilated ICU patients.

Treatment of hypotension of prematurity: a non-blinded cohort clinical trial

To compare neonatal mortality and short-term (advanced MRI indices of structural brain injury at 40 weeks* GA) and long-term neurodevelopmental outcomes (Bayley scales of infant development III [BSID-III] at 24 months) between two groups of very…

Norepinephrine for the management of hypotension in premature and full-term neonates

To investigate if norepinephrine is safe and effective in increasing blood pressure and systemic blood flow in premature and full-term neonates with shock and/or hypotension.

Cytokine adsorption for vasoplegic syndrome after cardiothoracic surgery

We aim to investigate the clinical benefit of cytokine adsorption on post-cardiothoracic surgery vasoplegic syndrome.

Microcirculatory perfusion alterations in severe burn injury

Primary Objective: To assess the incidence of microcirculatory perfusion alterations, according to a predefined arbitrary cut off value, in patients with severe burns injury (>15%TBSA) during standard resuscitation in the first 24 hours.