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A Double-blind, Randomised, Placebo-controlled, Phase 2b/3 Adaptive Clinical Trial Investigating the Efficacy and Safety of Selepressin as Treatment for Patients with Vasopressor-dependent Septic Shock

To demonstrate superiority of selepressin plus standard care versus placebo plus standard care in the number of vasopressor- and mechanical ventilator-free days (with penalty for mortality) in patients with vasopressor-dependent septic shock

IMPella versus IABP REduces mortality in STEMI patients treated with primary PCI IN SEVERE and deep cardiogenic SHOCK.
An international multicenter, randomized trial of the Impella cVAD (left ventricular assist) device versus Intra Aortic Balloon Counter Pulsation (IABP) therapy for acute ST-elevation myocardial infarction patients treated with primary PCI in severe and deep cardiogenic shock

The primary objective of this study is to determine whether the Impella cVAD device vs. IABP therapy leads to a higher 30 day survival rate in shock STEMI patients in the setting of primary PCI.

Study on the effects of hyperoxemia on hemodynamic parameters and cardiac function

To study dose-dependent hemodynamic and microcirculatory changes during oxygen supply in mechanically ventilated ICU patients.

Phenylephrine versus EPhedrine on cerebral Perfusion during Carotid EndarteRectomy

Primary Objective: Our primary objective is to study the influence of two routinely used drugs to increase systemic blood pressure (phenylephrine and ephedrine) on cerebral oxygenation and perfusion, estimated by changes in cerebral oxygenation (…

Treatment of hypotension of prematurity: a non-blinded cohort clinical trial

To compare neonatal mortality and short-term (advanced MRI indices of structural brain injury at 40 weeks* GA) and long-term neurodevelopmental outcomes (Bayley scales of infant development III [BSID-III] at 24 months) between two groups of very…

The effect of sevoflurane and isoflurane on vasopressor need

Aim of this study is to determine the effect of isoflurane versus sevoflurane on blood pressure and systemic vascular resistance.

Norepinephrine for the management of hypotension in premature and full-term neonates

To investigate if norepinephrine is safe and effective in increasing blood pressure and systemic blood flow in premature and full-term neonates with shock and/or hypotension.

Microcirculatory perfusion alterations in severe burn injury

Primary Objective: To assess the incidence of microcirculatory perfusion alterations, according to a predefined arbitrary cut off value, in patients with severe burns injury (>15%TBSA) during standard resuscitation in the first 24 hours.

Cytokine adsorption for vasoplegic syndrome after cardiothoracic surgery

We aim to investigate the clinical benefit of cytokine adsorption on post-cardiothoracic surgery vasoplegic syndrome.