19 results
The principal objective of the study is to determine if the performance of the new technique (magnetic tracer and magnetometer) is equivalent to the performance of the standard technique (patent blue dye and radioisotope, wire localization).The…
Up front breast surgery in patients with primary distant metastatic breast cancer, will result in an improvement of the 2-year survival compared to the survival achieved with systemic therapy and delayed local treatment or systemic therapy alone.The…
The principal objective of the study is to determine if the performance of the new technique (magnetic tracer and magnetometer) is equivalent to the performance of the standard technique (patent blue dye and radioisotope; or radioisotope alone).The…
To measure the wavelength dependent differences in optical properties between normal and malignant breast tissue over a broad wavelength range (400-1000 nm).
The objective of this study is to determine the accuracy of the sentinel lymph node biopsy in multicentric breast cancer prospectively and multi-institutional.
Research question: Is microbubble-enhanced Iodine-125 seed localization an accurate tool for preoperative identification of the sentinel lymph node in women with breast cancer, in terms of diagnostic accuracy, sensitivity, feasibility, patient…
MULTICENTER FEASIBILITY STUDY OF THE SENTINEL NODE PROCEDURE IN PATIENTS WITH MULTIPLE BREAST TUMORS
The aim of the study is to validate the sentinel node procedure in breast cancer patients with multiple tumors and to investigative whether an intratumoral injection of the radiopharmaceutical in each tumor will result in additional sentinel nodes…
Detection of breast carcinoma with an ICG enhanced optical imaging device in breast cancer patients.
Ergonomics and function of the imaging system - the NIRF imaging system should not interfere with the standard lumpectomy procedure and used safely by the surgeon while detection of ICG within the tumour takes place. Duration: 1,5 hour clinical…
Pilot for determining the feasibility and image quality of high resolution Tc99m-SestaMIBI imaging of lumpectomy specimens for detection, localization, and quantification of resection margins.
Primary Objectives: Investigate whether the usage of pre-operative projections prior to a deep inferior epigastric perforator flap breast reconstruction leads to more correctly identified perforator locations and less operation time spend on…
This study aims to develop a prediction rule for PMPS one year after breast surgery based on neurophysiological, psychological, and clinical parameters. Based on this prediction, individualized perioperative management and postoperative revalidation…
The primary objective of this study is to analyse the feasibility and internal validity of Magtrace in the sentinel node procedure in breast cancer in the Breast Care Centre in Zuyderland Medical Centre; with the ultimate goal to make the sentinel…
This study is designed as a single-center diagnostic accuracy study. The duration of the study is 2 years. To introduce tissue sensing during the stereotactic VABB, we developed an optical introducer with DRS fibers that can be integrated with the…
To test whether the use of magnetic localization seeds causes image artifacts on CEM.
PRIMARY QUESTIONDuring the sentinel node procedure in breast cancer patients, does a 3D SPECT/CT protocol not lead to a longer operation time to remove axillary sentinel nodes, compared to the 2D standard protocol?• H0: OK-time(SPECT/CT) - OK-time(…
Primary objectives -To determine whether real-time tumor visualization using targeted fluorescent imaging during breast conserving therapy in breast cancer patients can be achieved intraoperatively and results in adequate assessment of the tumor…
The primary objective is to assess the feasibility of intraductal biopsy and intraductal laser ablation in patients with intraductal lesions. Secondary objectives are: treatment success of interventional ductoscopy (biopsy and laser ablation) in…
To assess whether core biopsies of the breast after neoadjuvant chemotherapy can reliably predict a pathologic complete response. We will therefore calculate the sensitivity, specificity, positive predictive value and negative predictive value of…
The main goal of this study is to examine the accuracy (identification rate of the MARI-node and Sentinel node, sensitivity, negative predictive value (NPV) and false-negative rate (FNR)) of the RISAS procedure compared to the current standard…