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REPRISE II: Repositionable Percutaneous Replacement of Stenotic Aortic Valve through Implantation of Lotus Valve System - Evaluation of Safety and Perfomance

To evaluate the safety and performance of the Lotus Valve system for transcathether aortic valve replacment (TAVR) in symptomatic subjects with severe calcific aortic stenosis who are considered high risk for surgical valve replacement.

The POSTIVE (Pre-Operative STatin InterVEntion) study

This study will test the hypothesis that acute administration of statins will provide for a better protective (anti-inflammatory) effect than chronic administration. Patients used for this study have to undergo mitral and/or tricuspid valve surgery…

A randomized open pharmacokinetic pilot study on bIAP, an anti-inflammatory moiety, in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.

Primary Objective:The objective of this pilot study is to determine whether the observed AP pharmacokinetic profiles in plasma of CABG patients in the APPIRED study can be confirmed in the CABG patients under a non-aprotinin regime.