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Comparison of BIOdegradable Polymer and DuRablE Polymer Drug-eluting Stents in an
All COmeRs PopulaTion (BIO-RESORT): Randomized Multicenter Trial in an All Comers Population Treated Within thE NeThErlands 3 (TWENTE 3)

The aim of the study is to compare the outcome of two DES with biodegradable polymer coatings separately (Orsiro and Synergy) versus an established third-generation durable polymer DES with proven efficacy and safety (Resolute Integrity) in an all…

DUrable Polymer-based STent CHallenge of Promus ElemEnt versus ReSolute Integrity (DUTCH PEERS): Randomized Multicenter Trial in All-Comers Population Treated Within
Eastern NeThErlands-2 (TWENTE-2)

Primary research questions To investigate whether the outcome after the randomized implantation of the Resolute Integrity® versus Promus Element® drug-eluting stent are similar, as assessed in a non-inferiority setting by comparing target-vessel…

Local gentamicin in Redon treated post-sternotomy mediastinitis

The aim of our study is to evaluate clinical outcomes of patients primarily closed over Redon catheters for the treatment of PSM, comparing the application of local gentamicin with a control group.

Administration of warm blood cardioplegia with or without roller pump; a comparison.

The aim of the study is to evaluate the effect of warm blood cardioplegia administration without rollerpump on perioperative myocardial injury in patients undergoing coronary artery bypass grafting (CABG) with a minimal extracorporeal circuit (MECC…

The effect of a high and low protamine-to-heparin dosing on perioperative hemostasis:
a randomized clinical trial

Does a low protamine-to-heparin ratio lead to a reduction in postoperative blood loss and improved postoperative hemostasis when compared to a high protamine-to-heparin ratio in cardiothoracic surgery?

The effect on cerebral oxygenation of retrograde autologous priming of the CPB circuit in cardiac surgery patients: a Randomized Controlled Trial

Primary Objective: The primary objective of this study is to determine whether RAP limits the degree of hemodilution and limits prolonged intraoperative cerebral desaturation during during CPB, compared to the conventional priming method. Prolonged…

The effect on blood loss of topical and intravenous tranexamic acid in cardiac surgery patients: a randomized placebo-controlled trial

Primary Objective: the objective of this study is to determine whether the application topical TA into the pericardial cavity just before sternal closure reduces the 12 hours post-operative blood loss by 25% after cardiac surgery patients on…

A(f)MAZE-CABG study;A PROSPECTIVE RANDOMIZED TRIAL COMPARING FREEDOM FROM ATRIAL FIBRILLATION AT 1 YEAR POST CABG IN PATIENTS UNDERGOING CONCOMITANT LEFT ATRIAL ABLATION USING HIGH INTENSITY FOCUSED ULTRASOUND (HIFU) VERSUS CABG ALONE IN PATIENTS WITH PERSISITENT OR LONG STANDING PERSISTENT ATRIAL FIBRILLATION ;Study Code: AF07004AF

Concomitant AF ablation with HIFU in patients with persistent or long standing persistent AF undergoing CABG will be superior in restoring SR, compared with patients with persistent or long standing persistent AF undergoing CABG treated with best…

A Prospective, Randomized, Multicenter Trial to Assess an Everolimus-Eluting Coronary Stent System (PROMUS Element*) for the Treatment of up to two De Novo Coronary Artery Lesions

To determine the safety and effectiveness of the PROMUS Element* Everolimus-Eluting Coronary Stent System (Boston Scientific Corporation [BSC], Natick, MA) for the treatment of patients with up to 2 de novo atherosclerotic lesions

A comparison of the use of mini extracorporeal circuits with conventional extracorporeal circuits and with further miniaturized mini extracorporeal circuits in CABG patients.

This study will evaluate if the use of a mini extracorporeal circuit is an improvement for the patient. The study investigates how much the use of a mini extracorporeal circuit will change the homologous blood requirements and the magnitude of the…

BIoresorbable polymer-coated ORSIRO versus durable polymer-coated RESOLUTE ONYX stents [BIONYX]: A randomized Trial With stENT Evaluation in all-comers IV [TWENTE IV]

The aim of the study is to compare the outcome of the bioresorbable polymer coated stent (ORSIRO) and a new generation permanent polymer coated stent (RESOLUTE ONYX) in an allcomers patient population and non-inferiority setting.

Advanced Image Supported Left Ventricular Lead Placement in Cardiac Resynchronization Therapy III

To establish the efficacy of targeted LV lead delivery in a sufficiently powered randomized, multicentre study. Efficacy is determined based on the distance of the LV-lead to the targeted cardiac segment, as determined pre-implantation by CARTBox.

CYtosorb modulation of surgiCal infLammatiON during LVAD insErtion (CYCLONE-LVAD)

The four principle objectives of this study are:1. To investigate the efficacy of Cytosorb® treatment in attenuating perioperative changes in IL-6 during CF-LVAD implantation 2. To investigate the feasibility, and safety of Cytosorb® treatment…

REnal function after PULSatile blood flow during cardiopulmonary bypass in cardiac surgery

Does pulsatile blood flow during cardiopulmonary bypass lead to a reduction in the average increase in postoperative creatinine levels in patients with preoperative renal dysfunction when compared to non-pulsatile blood flow?