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Pericardial Tissue and the Post Pericardiotomy Syndrome

1. To get new insights in the pathophysiology of PPS by comparing tissue characteristics (histology) of the pericardium in patients with and without PPS. 2. To identify biomarkers that are associated with PPS by collecting 4 blood- and 1 pericardial…

Aortic root changes after percutaneous atrial septal defect closure; Insights towards understanding the mechanism and predictors of device erosion and aortic valve dysfunction.

The primary objective is to investigate the determinants of aortic root deformation occurring >= 3 months after successful ASO implantation in adult patients with an atrial septal defect.

A randomized, double-blind, placebo-controlled phase IIIa study of bIAP, an anti-inflammatory moiety, in patients undergoing combined aortic valve replacement and coronary artery bypass grafting.

Primary Objective:The objective of this study is to determine the efficacy of bIAP as a prophylactic agent against inflammation-mediated complications from more invasive cardiac surgery, aortic valve surgery and CABG with cardiopulmonary-bypass time…

Prevention Decline in Older Invasive Cardiac Surgery Patients

Study question and objective At this stage of developement of the multicomponent is intervention it is unclear whether the intervention is feasible in practice. Therefore the question: Is this multicomponent preadmission intervention feasible in…

The ATACAS Trial: Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial. A prospective, randomised, double blind, factorial trial testing whether aspirin, tranexamic acid, or both, can reduce mortality and/or major morbidity after elective coronary artery surgery.

Should low-dose aspirin be continued up until the day of CABG or OPCAB surgery?Should TxA be used for all at-risk CABG or OPCAB surgery?

Postoperative Pericardial Flush, to evaluate the effects of pericardial flush with a crystalloid on blood loss after valvular surgery and correction for CHD.

Primary objective: To determine whether postoperative pericardial flush with a crystalloid can reduce postoperative blood loss by effectively removing contaminated pericardial blood after valvular surgery and correction for CHD. The primary…

Right Atrial Pacing versus Left Atrial Pacing to Prevent Development of Paroxysmal Atrial Fibrillation in Patients with Sick Sinus Syndrome or Anti-arrhythmic Drug-induced Bradycardia.

- To determine the effects of the pacing site on prevention of AF episodes - To examine the relation between the pacing site, reduction of AF episodes, quality of life, heart failure, number of cardioversions, frequency and duration of hospital…

Pre-operative treatment with Erythropoietin and iron supplement for prevention of perioperative blood transfusion in cardiac surgery

Primary objective: To determine the reduction of number of patients who receive blood transfusion perioperatively in the group pre-treated with erythropoietin and iron supplement compared to the control patients.

Postoperative new-onset atrial fibrillation in cardiac surgery: An explanatory study of the prophylactic effect of corticosteroids (DECS-PNAF project)

The aim of this project is to elucidate how corticosteroids protect cardiac surgical patients from PNAF. We will therefore examine the modulating effect of prophylactic high-dose corticosteroid administration on perioperative risk factors for PNAF.…

Cerebral perfusion during neonatal cardiac surgery: Can we improve outcome?

In a randomized controlled trial, the effects of DHCA and ACP during complex neonatal cardiac surgery on organ function and injury will be compared, especially focusing on cerebral damage and neurological outcome. The primary research question is…

The occurrence of cerebral embolism (CE) in catheter ablation of atrial fibrillation (AF) using three different ablation catheters

1. To compare the induction of a procoagulant state between patients undergoing PVI using the PVAC catheter, the cryoballoon catheter or the cooled tip catheter.2. To compare the incidence of CE on diffusion weighted MRI between the three groups of…

A clinical study to investigate the effects of remote ischemic preconditioning on cardiac mitochondrial hexokinase in CABG patients

The aim of this clinical study is to investigate whether RIPC induced cardioprotection is associated with an increased amount of mitochondrial HK (mtHK) in the heart.

Comparison of cerebral tissue oxygen desaturation in patients undergoing on-pump or off-pump coronary artery bypass grafting

The goal of this study is to determine if off-pump CABG surgery is associated with better cerebral tissue oxygenation when compared with on-pump CABG. In addition, we would like to compare the results of two different monitors of brain tissue…

Fontan circulation: Analysis of its Impact on quality of life and Rate of deterioration (FAIR study)

Primary Objective: - Investigating the rate of the attrition and predictors of the failing Fontan circulation, defined as decrease in functional capacity. Secondary Objective(s): - Investigating predictors of decrease in NYHA class of Fontan…

Perioperative changes in the microvascular perfused boundary region in patients undergoing coronary artery bypass grafting

To identify the influence of two different biocompatible-coated extracorporeal circuits on the perfused boundary region of the sublingual microvasculature as measured by the GlycoCheck Sidestream Darkfield Imaging camera.

Thirty years arterial switch operation for transposition of the great arteries; a follow-up study.

The main objectives are 1) is to evaluate the prevalence of cardiac complications long-term after ASO by investigation of cardiac function as well as clinical outcome and to determine which factors (associated with life style or operative techniques…

Efficacy and safety of Haemocomplettan® P in patients experiencing microvascular bleeding while undergoing elective complex cardiac surgery

To determine whether fibrinogen concentrate infusion reduces perioperative blood loss and transfusion in patient experiencing clinically relevant microvascular bleeding during elective complex cardiac surgery and to determine whether its use is safe…

A clinical study to investigate the molecular effects of remote ischemic preconditioning in the myocardium of CABG patients with or without diabetes mellitus

The aim of this clinical study is to investigate whether remote ischemic preconditioining induces an activation or phosphorylation of signalling pathway molecules (MAPK) in myocardium in patients undergoing coronary artery bypass graft (CABG)…

Does have autologous blood withdrawal pre-operative with and without sequestration, effect on the usage of allogeneic bloodproducts during and after heartsurgery.

When it is possible to prove that there is a significant difference between the sequestration group and the other two groups, it also will be possible for patients with a smaller body surface to donate autologous blood and also this group will need…

Do washed irradiated red blood cells with a balanced solution improve the quality of the priming in cardiopulmonary bypass for neonates and infants?

Improve the quality of red blood cells used for cardiopulmonary bypass for neonates and infants with a bodyweight smaller then 10 Kg.