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Fixed versus variable dosing strategy of prothrombin complex concentrate for bleeding complications of vitamin K antagonists

To test whether the clinical outcome of lower fixed dose of PCC is superior to higher variable dose of PCC, for VKA related bleeding in a randomized setting. Secondary objectives include the comparison of INR after administration of PCC, time to…

Targeted Abdominal Lymph nodE dissections randomized for surgical NavigaTion (TALENT)

To evaluate if navigation assistance results in more successful localization and removal of extra-regional abdominal lymph nodes compared to standard surgery. Extra regional lymph nodes are defined as suspect target lymph nodes outside the standard…

The LYMPH Trial - Surgical versus Conservative Complex Physical Decongestion Therapy for Chronic Breast Cancer-Related Lymphedema: A Pragmatic, Randomized, Multicenter Superiority Trial

Primary Objective:The primary objective of this trial is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, upper limb, questionnaire) 15 months after randomization (and therefore about one year after surgery)…