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Clinical assessment of a new adhesive and HME for night-time use in laryngectomized patients: Provox Luna

The objective of this clinical investigation is to evaluate the clinical performance of Provox Luna in comparison to the usual care of the patient.

Implantology and Sjögren*s syndrome: a multicenter prospective cohort study

To investigate changes in marginal peri-implant bone loss and the clinical performance of dental implants in SS patients compared to implants in healthy patients.

Mandibular Advancement Device (MAD) therapy in edentulous patients with obstructive sleep apnea: dental implant fixed MADs vs. CPAP.

The main purpose of this pilot study is to assess the feasibility and potential efficacy of implant retained mandibular advancement device (MAD) therapy on a small scale in edentulous patients with mild to moderate OSA in comparison to CPAP therapy…

Combination of salvage surgery and adjuvant photodynamic therapy in management of recurrent or residual sinonasal tumors.

The main objective of this study is to develop a PDT and salvage surgery combination specific for recurrent or residual tumors of the sinonasal cavities, unsuitable for the conventional treatments like radical surgery or radiotherapy with curative…

The effects of propranolol on fear of tooth removal: A randomized, placebo-controlled, double-blind, parallel design trial

The aim of this study is to determine the effects of propranolol on patients* crucial fear-related memories and dental trait anxiety in those undergoing surgical removal of one of their teeth or molars. The hypotheses that are tested are that…

Bèta-TCP (bèta-tricalcium phosphate) as a bone substitute in patients undergoing repair of the alveolar cleft in CLP(Cleft Lip Palate) patients.

This current study aims to investigate the use of Curios bèta-TCP, a synthetic tricalcium phosphate for repair of the alveolar cleft in patients with clefts of lip, alveolus and palate.The specific properties of Progentix TCP result in optimal and…

A multi center, prospective, randomized controlled trial comparing cervical arthroplasty to anterior cervical discectomy and fusion (ACDF) for the treatment of cervical degenerative disc disease.

The primary objective of this investigation is to evaluate the performance of the DISCOVER Artificial CervicalDisc in the treatment of cervical disc disease by measuring the function assessed via Neck Disability Index(NDI) and neurological function…

COSMIC: Conservative or early Surgical Management of Incomplete cervical Cord syndrome without spinal instability. Randomized controlled trial

To compare the efficacy of early decompressive surgery to improve functional outcome in patients with cevical incomplete cord lesion without a fracture or instability of the cervical spine compared to those receiving conservative treatment.

Clinical assessment of a new speaking valve for hands-free speech in laryngectomized patients: Provox® FreeHands FlexiVoice

The objective of this clinical investigation is to evaluate the short- and long-term clinical feasibility of the Provox FreeHands FlexiVoice, in combination with the currently available attachments, and explore its limitations and advantages.

Long term biomechanical effects of bimaxillary transverse expansion

Primary Objective: • To assess the short and long-term (> 3 years) biomechanical effects of SARME and MMD. Secondary Objective(s): • To assess the long-term (> 3 years) biomechanical effects of MMD and SARME. • To assess if a…

Taste, Speech and oro-facial relations following partial tongue reduction: A single-center, longitudinal, functional outcome study in patients with Beckwith-Wiedemann Syndrome that have undergone tongue reduction surgery

The aim of this study is to investigate the long-term outcomes in patients with BWS that have been surgically treated at our institution with the help of simple, non-invasive, objective study tools. We hope to gain valuable information regarding the…

Electrochemotherapy in head and neck cancer patients

The primary objective of this study is to determine the response rate of electrochemotherapy in head and neck cancer. Secondary objectives are to monitor local and systemic side effects and adverse events and to determine quality of life before and…

Clinical Feasibility of a new adhesive base plate (placeholder for stoma appliances) for rehabilitation after total laryngectomy

To investigate the clinical feasibility of the Provox StabiliBase adhesive.

Conventional tonsillectomy versus outpatient CO2-lasertonsillotomy in adult patients; a randomised controlled trial

The purpose of this study is to demonstrate the effectiveness of treatment using the CO2-laser in one selected group of patients compared with a classical tonsillectomy. We also compare peri-operative en post-operative morbidity, pain, complications…

A Randomised Controlled Clinical Trial comparing the results of the Immediate Loading (within 48 hours) of Mandibular Overdentures supported by either 2 standard Straumann dental implants or 4 Mini Dental Implants (MDIs).

In this randomized controlled clinical trial we aim to apply the-already investigated-concept of immediate loading protocol and examine the performance of implant-retained overdentures using 2 SLAactive Straumann implants connected by bar ( Contol…

Early clinical feasibility study of a new voice prosthesis: the Provox Vega HP

The objective of this clinical investigation is to evaluate the short-term clinical feasibility of Vega HP and explore its limitations and advantages. As a result of the evaluations, design changes may be implemented and evaluated until the optimal…

Cervical spine movement, before and after anterior cervical discectomy (ACD).
ACD, pure intervertebral discectomy (1) compared to intervertebral discectomy followed by implantation of an intervertebral disc prosthesis (2) in patients with a radicular syndrome. A randomised study

Objective of the study is to verify whether the movement pattern after anterior cervical discectomy normalises, in case of implantation of a cervical disc prosthesis.

A MULTI-CENTRE, PROSPECTIVE, POST MARKETING SURVEILLANCE STUDY INVESTIGATING THE PERFORMANCE OF CERVICAL ARTHROPLASTY FOR THE TREATMENT OF CERVICAL DEGENERATIVE DISC DISEASE (DDD)

The primary objective of this investigation is to evaluate the performance of the DISCOVER Artificial Cervical Disc in the treatment of cervical disc disease by measuring the function assessed via Neck Disability Index (NDI) and neurological…

Effectiveness of postoperative radiotherapy in patients with oral or oropharyngeal squamous cell carcinoma and histologically confirmed single ipsilateral lymphnode metastasis (pN1)

To determine the optimal therapy for patients with pT1-2 pN0 oral and oropharyngeal cancer

Closure of oroantral communications using biodegradable polyurethane foam; a prospective clinical trial

Goal of this study is to assess the treatment of OACs with biodegradable polyurethane foam, as carried out in the pilot studies, in a large number of patients.