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Inguinal or Ilio-inguinal Lymphadenectomy for Patients With Metastatic Melanoma to Groin Lymph Nodes and no Evidence of Pelvic Disease on PET/CT Scan - A Randomised Phase III Trial (EAGLE FM)

This study aims to provide a more rational evidence base for appropriate management for metastatic melanoma in the groin LNs, through assessing the effect of the addition of ipsilateral pelvic lymphadenectomy on patient disease-free survival (DFS),…

Within-patient comparison of Senti-Scint and ICG-99mTc-nanocolloid for sentinel node biopsy of melanoma of the head and neck, of the trunk or of an extremity

To compare ICG-99Tc-nanocolloid to 99mTc-Senti-Scint for sentinel node mapping in patients with malignant melanoma of the trunk, an extremity or in the head and neck area.

In vivo identification of peripheral nerve bundles during surgery using optical spectroscopy techniques: a pilot study

With this pilot study we aim to prove that our optical spectroscopy system can provide accurate identification of nerve tissue during surgery.

Sensibility of the upper eyelid after blepharoplasty

The objective of this study is to find the prevalence and type of sensibility problems after upper blepharoplasty. Also we will study the postoperative course of possible problems in sensibility.

The development of secondary hyperalgesia after high frequency electrical stimulation (HFS) of the skin in patients with and without chronic postoperative pain after inguinal hernia repair.

To identify the mechanism(s) of pain in patients with chronic pain after inguinal hernia repair.

The anterior cutaneus nerve entrapment syndrome (ACNES). Randomized double blind controlled trial for the diagnosis and treatment of entrapment of the anterior cutaneus nerve through the rectus muscle.

Evaluation of the effect ofdiagnostic and therapeutic proces in reducing pain in patients suspected with ACNES.Is injection of lidocaine in patients suspected of ACNES leading to a larger group of people with a clinically relevant reduction of pain…

MELAMAG Trial: SentiMAG Melanoma - Sentinel Node Biopsy using Magnetic Nanoparticles: A prospective multicentre feasibility non-randomised clinical trial to compare sentinel node biopsy using magnetic nanoparticles vs. standard technique.

The principal objective of the study is to determine if the performance of the new technique (magnetic tracer and magnetometer) is equivalent to the performance of the standard technique (patent blue dye and radioistope; or radioisotope alone). The…

Wireless Laser Speckle Contrast Imaging Device for the visualisation of the microcirculatory during DIEP flap breast reconstruction.

This study aims to demonstrate that the new generation of the HAPI, the Wireless Perfusion Imager (WIPI) is able to visualise the microcirculation of the abdominal flap and the newly reconstructed breast during DIEP flap breast reconstruction. The…

Determining critical thresholds of tissue perfusion using indocyanine green in reconstructive surgery

Our primary objective is to determine critical values of tissue perfusion for reconstructive surgery be quantification using near-infrared fluorescence. The fluorescence signal will be derived from a signal to noise ratio. The primary outcome…