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A Phase 2, Single dose, Open-Label, Exploratory Study to Investigate the Safety and Efficacy of OTL38 Injection for Intraoperative Imaging of Folate Receptor Positive Lung Nodules

4.1 Primary• To estimate the Sensitivity and False Positive rate of OTL38 for malignancy detection during Near Infrared Imaging (NIR).• To assess the safety and tolerability of single intravenous doses of OTL384.2 Secondary• To assess the safety of…

Bronchoscopy: Oral versus Nasal introduction

The aim of this study is to compare nasal and oral insertion and to determine which of them is more comfortable and less time consuming for the patient.

A multicenter study evaluating the diagnostic value for vascular abnormalities of High Definition Bronchoscopy when combined with i-scan Imaging Technology compared to High Defintion Bronchoscopy alone

Primary objective:Determing the positive predictive value and diagnostic yield of HD+ i-scan bronchoscopy for vascular pattern detection .Secondary objectives:1. To investigate the correlation of vascular abnormalities with histology2. To…

High Definition bronchoscopy, an exploratory study of diagnostic value in comparison to standard white light bronchoscopy and autofluorescence bronchoscopy

(1) Investigate diagnostic performance (sensitivity) of HD bronchoscopy, with or without surface enhancement or tone enhancement in comparison to standard WLB for detecting abnormalities of the tracheobronchial tree. Furthermore we aim to…

platelet activation in lung transplantation

To establish platelet function and primary hemostasis during lung transplantation

AN OPEN-LABEL, EXPLORATORY STUDY ASSESSING THE FEASIBILITY OF SGM-101, A FLUOROCHROME-LABELED ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY FOR THE INTRAOPERATIVE DETECTION OF LUNG METASTASIS IN COLORECTAL CANCER

1. To determine the feasibility of SGM-101 for intraoperative imaging of colorectal lung metastases - Concordance between fluorescent signal and tumor status of resected tissue2. To define the optimal dose of SGM-101 for intraoperative imaging of…

Laparoscopic laser speckle contrast imaging for the demarcation of lung segments

In this trial we will study the utility of PerfusiX-Imaging for the identification of intersegmental planes during thoracoscopic segmentectomy.

Inflammation and complications after pulmonary surgery for cancer

Primary Objective: - To identify relative IL-6 thresholds (% increase from baseline and % decrease from the peak postoperative value) for predicting infectious complications after pulmonary surgerySecondary Objective(s): - To identify relative IL-6…

Velopharyngeal insufficiency after maxillomandibular advancement in obstructive sleep apnea patients

To examine the course of velopharyngeal insufficiency after maxillomandibular advancement in patients with obstructive sleep apnea.