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A Phase 2, Single dose, Open-Label, Exploratory Study to Investigate the Safety and Efficacy of OTL38 Injection for Intraoperative Imaging of Folate Receptor Positive Lung Nodules

4.1 Primary• To estimate the Sensitivity and False Positive rate of OTL38 for malignancy detection during Near Infrared Imaging (NIR).• To assess the safety and tolerability of single intravenous doses of OTL384.2 Secondary• To assess the safety of…

Bronchoscopy: Oral versus Nasal introduction

The aim of this study is to compare nasal and oral insertion and to determine which of them is more comfortable and less time consuming for the patient.

A multicenter study evaluating the diagnostic value for vascular abnormalities of High Definition Bronchoscopy when combined with i-scan Imaging Technology compared to High Defintion Bronchoscopy alone

Primary objective:Determing the positive predictive value and diagnostic yield of HD+ i-scan bronchoscopy for vascular pattern detection .Secondary objectives:1. To investigate the correlation of vascular abnormalities with histology2. To…

High Definition bronchoscopy, an exploratory study of diagnostic value in comparison to standard white light bronchoscopy and autofluorescence bronchoscopy

(1) Investigate diagnostic performance (sensitivity) of HD bronchoscopy, with or without surface enhancement or tone enhancement in comparison to standard WLB for detecting abnormalities of the tracheobronchial tree. Furthermore we aim to…

Short Term Effect of a Heat and Moisture Exchanger on Tracheal Mucociliary Clearance in Laryngectomized Individuals

Primary: Assessment of the short-term effect of a Heat and Moisture Exchanger on tracheal mucociliary clearance in laryngectomized individuals. Secondary: The relationship between clinical assessment, ciliary activity and mucociliary clearance.

Prospective cohort study on the effect of surgical treatment of obstructive sleep apnea syndrome on blood pressure (and other cardiovascular risk factors).

In The Netherlands 2% of women and 4% of men suffer from Obstructive Sleep Apnea Syndrome (OSAS). NCPAP, the gold standard therapy for moderate to severe OSAS has been shown to reduce blood pressure in OSAS. NCPAP therapy is however hampered by…

Perioperative decongestion and hemostasis, and postoperative analgesia for FESS after intranasal application of cocaine, tetracaine-oxymetazoline or ropivacaine-oxymetazoline

Het bestuderen en vergelijken van cocaïne, tetracaïne-oxymetazoline en ropivacaïne-oxymetazoline wat betreft de peroperatieve decongestie en hemostasis en postoperatieve analgesie die zij bieden bij FESS. Study and compare the peroperative…

platelet activation in lung transplantation

To establish platelet function and primary hemostasis during lung transplantation

Daily physical activity of lung cancer surgical patients: A pilot study

To examine the predictive value of daily physical activity (steps/day) (DPA) of lung cancer surgical patients, measured by a pedometer, on postoperative morbidity.To examine the relationship between the daily physical activity (pedometer-assessed…

AN OPEN-LABEL, EXPLORATORY STUDY ASSESSING THE FEASIBILITY OF SGM-101, A FLUOROCHROME-LABELED ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY FOR THE INTRAOPERATIVE DETECTION OF LUNG METASTASIS IN COLORECTAL CANCER

1. To determine the feasibility of SGM-101 for intraoperative imaging of colorectal lung metastases - Concordance between fluorescent signal and tumor status of resected tissue2. To define the optimal dose of SGM-101 for intraoperative imaging of…

Laparoscopic laser speckle contrast imaging for the demarcation of lung segments

In this trial we will study the utility of PerfusiX-Imaging for the identification of intersegmental planes during thoracoscopic segmentectomy.

Virtual reality exposure before elective pediatric day-care surgery: effects on pre- and postoperative anxiety and pain

The objective is:(1) To test the efficacy of VRE versus CAU in 200 children undergoing surgery on the anxiety level of the child during induction of anesthesia (primary outcome), pre- and postoperative child anxiety, pre- and postoperative parental…

Inflammation and complications after pulmonary surgery for cancer

Primary Objective: - To identify relative IL-6 thresholds (% increase from baseline and % decrease from the peak postoperative value) for predicting infectious complications after pulmonary surgerySecondary Objective(s): - To identify relative IL-6…

Velopharyngeal insufficiency after maxillomandibular advancement in obstructive sleep apnea patients

To examine the course of velopharyngeal insufficiency after maxillomandibular advancement in patients with obstructive sleep apnea.