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Spinal Bupivacaine/Morphine in laparoscopic gastro-intestinal surgery

The objective of this study is to determine if a single spinal shot of morphine can decrease post-operative opioid-use, and thereby decrease opioid side-effects and lead to a quicker recovery after surgery.

Reinforcement of closure of stoma site

To assess whether a biological mesh (collagen tissue matrix) reduces the incidence of clinically detectable stoma closure site hernias at two years compared to standard closure techniques.

Semi-mechanical versus hand sewn cervical anastomosis after esophagectomy with gastric tube reconstruction for esophageal cancer; the SHARE study

The primary objective of this study is to compare a semi-mechanical with a hand sewn cervical anastomosis after esophagectomy with gastric tube reconstruction for cancer.

Minimally invasive versus open pancreato-duodenectomy for pancreatic and peri-ampullary neoplasm (DIPLOMA-2): an international multicenter patient-blinded randomized controlled trial

The aim of DIPLOMA-2 is to compare MIPD with OPD regarding post-operative complications (non-inferiority) and time to functional recovery (superiority) for pancreatic and peri-ampullary neoplasm in high-volume centers in an enhanced recovery setting…

Efficacy, safety and tolerability of a bowel cleansing preparation (Eziclen®/Izinova®)
in paediatric subjects undergoing colonoscopy: a Phase III, multicentre, randomised, comparative study versus Klean-Prep® (PEG-Electrolytes), administered on the day before colonoscopy,
Investigator-blinded, non-inferiority in adolescents of 12 to 17 years of age (inclusive) > 40 kg.

Primary objective:To demonstrate that Eziclen, given on the day before colonoscopy has non-inferior efficacy to Klean-Prep on colon cleansing in adolescents aged 12 to 17 years (inclusive) with a body weight > 40 kg, scheduled to undergo a…

Laparoscopic versus robot-assisted left-sided pancreatectomy for benign and pre-malignant lesions (DIPLOMA-3): an international multicenter patient-blinded randomized controlled trial

To compare L-MILP with R-MILP for benign and pre-malignant lesions of the pancreas in high-volume centers, regarding:1. Peri- and postoperative outcomes in terms of COMPOS-panc left score, for non-inferiority2. Total hospital-related costs, for…

Longterm outcome of biological mesh closure of the pelvic floor after extralevator abdominoperineal resection for rectal cancer.

The aim of this study is to determine the cost-effectiveness of pelvic floor reconstruction using a biological mesh afterstandardized eAPR with neo-adjuvant (chemo)radiotherapy.