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Spinal Bupivacaine/Morphine in laparoscopic gastro-intestinal surgery

The objective of this study is to determine if a single spinal shot of morphine can decrease post-operative opioid-use, and thereby decrease opioid side-effects and lead to a quicker recovery after surgery.

A randomized clinical trial investigating LanreotIde For output reduction in patients with high-output Enterocutaneous fistula or enterostomie

To assess the impact of treatment with Lanreotide versus current standard of treatment on output reduction in patients with high output enterocutaneous fistula or high-output stoma.

Neo-adjuvant chemotherapy followed by surgery versus surgery alone in high-risk patients with resectable colorectal liver metastases ;The CHARISMA randomized multicenter clinical trial

The primary study objective is to compare the efficacy, as assessed by overall survival, of surgery and neo-adjuvant chemotherapy to surgery alone in patients with resectable liver metastases of colorectal cancer and a high clinical risk score.…

Node study: 'Esophageal resection for patients with esophageal cancer and cervical lymph node metastases'

To assess the safety and feasibility of curative esophagectomy combined with three field lymphadenectomy after chemo-radiation in Western patients with resectable thoracic esophageal carcinoma and cervical lymph node metastases in level III and/ or…

Neo-adjuvant chemotherapy, cytoreductive surgery with hypethermic intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal origin.

To investigate wether neo-adjuvant chemotherapy followed by cytoreductive syurgery and hyperthermic chemotherapy is feasible and reduces the number of irresectable patients with acceptable morbidity and mortality rates.

A Randomized Controlled Multicenter Study of an Incisionless Operating Platform for Primary Obesity vs. Diet-Exercise alone: The MILEPOST Study

The primary objective of this study is:* To evaluate the safety and effectiveness of the g-Cath* EZ Delivery Catheter with Snowshoe Suture Anchors* gastric procedure as an weight loss intervention compared to diet and exercise only.A key secondary…

Colorectal anastomosis protected by a biodegradable drain fixed to the anastomosis by a circular stapler. A Multi-Center Randomized Controlled Trial (C-seal study)

Primary objective: efficacy of the C-seal in reducing anastomotic leakage (AL).Secondary objectives: The number of dismantled anastomoses; AL within 30 days according to the ISGRC classification; interval between the operation and AL; The pain score…

Nutritional Route In Esophageal Resection trial

This study aims to determine whether early start of oral intake in patients that underwent an esophagectomy is feasible and safe.

Irreversible electroporation treatment in patients with pancreatic locally advanced adenocarcinoma

The objective of this study is to investigate the amount of clinically relevant complications (defined by Clavien-Dindo score 3 or higher) caused by IRE in patients with locally advanced, non-resectable, non-metastasized, pancreatic cancer.

Reinforcement of closure of stoma site

To assess whether a biological mesh (collagen tissue matrix) reduces the incidence of clinically detectable stoma closure site hernias at two years compared to standard closure techniques.

Semi-mechanical versus hand sewn cervical anastomosis after esophagectomy with gastric tube reconstruction for esophageal cancer; the SHARE study

The primary objective of this study is to compare a semi-mechanical with a hand sewn cervical anastomosis after esophagectomy with gastric tube reconstruction for cancer.

CHEMORADIOTHERAPY FOR RECTAL CANCER IN THE DISTAL RECTUM FOLLOWED BY ORGAN-SPARING TRANSANAL ENDOSCOPIC MICROSURGERY
CARTS study
CApecitabine, Radiotherapy and Tem Surgery. A PHASE II, FEASIBILITY TRIAL

Objective of this research is to evaluate whether neo-adjuvant chemo-/radiotherapy in small non-advanced rectal cancers can be used to obtain a complete or near complete remission. In these patients could a complete resection of the rectum as an…

transanal total rectal excision a hybrid notes procedure
the introduction of a new technique

The objective of this new approach is: to reduce the number of conversionsfaster recoveryshorter hospital stay

The analgesic efficacy of perioperative delta-9-THC (Namisol) in patients undergoing major abdominal surgery: a randomized, double blinded, placebo-controlled, parallel design

The primary aim of this study is to investigate the analgesic effect of perioperatively administered Namisol® to reduce postsurgical pain on the day of surgery and in the first five days after major abdominal surgery. A secondary aim is to…

Endoluminal fundoplication with the Esophyx*-device versus proton-pump-inhibition in treatment of Gastro-esophageal reflux disease (GERD).

The purpose of this prospective randomized controlled trial is to demonstrate that the EsophyX-TIF procedure will be more effective than PPI therapy as a short and long-term treatment of GERD.

A Multicenter Phase II Study of Neoadjuvant Docetaxel, Cisplatin and Capecitabine and Protocolized Surgery in Resectable Gastric Cancer
An IKZ-based phase II feasibility study

This study investigates the feasibility role of neoadjuvant chemotherapy, consisting of docetaxel (Taxotere), cisplatin and capecitabine (Xeloda) (TCX), and protocolized surgery in localized and/or locally advanced resectable gastric cancer (D1extra…

The C-Seal study: Colorectal anastomosis protected by a biodegradable drain fixed to the anastomosis by a circular stapler: a phase II study.

The primary objective of this second phase study is to estimate the occurrence of anastomotic leakage when the C-seal is used.Secondary objectives are:* Feasibility of applying the C-seal, especially considering the improved attachement to the…

A phase III randomized study evaluating surgery of residual disease in patients with metastatic gastro-intestinal stromal tumor responding to Imatinib mesylate.

The primary objective of this study is to evaluate whether surgery of residual disease in patients iwth advanced GIST responding to Imatinib improves the progression free survival.The secondary objective is to correlate the pharmacokinetics of…

Non-randomised,open, multi-center trial evaluating feasibility and safety of Tachosil application on a colorectal anastomosis

The primary efficacy variable is if the TachoSil application was feasible. A feasible application implies that the entire TachoSil adhere, TachoSil covers at least 1 cm beyond the margins of the anastomosis line and if more TachoSil sponges are used…

Standard CONservative approach versus endoscopic Debridement in patients with symptomatic sterile Organized pancreatic necRosis (CONDOR trial): a prospective randomised controlled trial

To compare endoscopic transmural debridement with standard conservative treatment in patients with symptomatic sterile organized pancreatic necrosis in a randomized controlled trial with emphasis on extent and duration of recovery.